Cited 4 times in
Carbon monoxide-releasing molecule-3: Amelioration of renal ischemia reperfusion injury in a rat model
DC Field | Value | Language |
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dc.contributor.author | 신수진 | - |
dc.date.accessioned | 2020-12-11T07:53:26Z | - |
dc.date.available | 2020-12-11T07:53:26Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2466-0493 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180699 | - |
dc.description.abstract | Purpose: Despite the role of carbon monoxide in ameliorating ischemia-reperfusion injury (IRI), its use in the clinical setting is restricted owing to its toxicity. Herein, we investigated the in vivo effects of carbon monoxide-releasing molecule-3 (CORM-3) on IRI. Materials and methods: Fifteen rats were equally and randomly divided into three groups: sham (right nephrectomy), control (right nephrectomy and left renal ischemia), and CORM-3 (right nephrectomy and CORM-3 injection before left renal ischemia). Kidney tissues and blood samples collected from sacrificed rats were evaluated to determine the renoprotective effect and mechanism of CORM-3. Results: Concentrations of serum creatinine and kidney injury molecule-1 in the CORM-3 group were significantly lower than in the control group after 75 minutes of IRI (1.2 vs. 2.4 mg/dL, p=0.01, and 292 vs. 550 pg/mL, p<0.001, respectively). Furthermore, the CORM-3 group exhibited a higher portion of normal tubules and glomeruli. TUNEL staining revealed fewer apoptotic renal tubular cells in the CORM-3 group than in the control group. The expression of 960 genes in the CORM-3 group was also altered. Pretreatment with CORM-3 before renal IRI produced a significant renoprotective effect. Fifteen of the altered genes were found to be involved in the peroxisome proliferator-activated receptors signaling pathway, and the difference in the expression of these genes between the CORM-3 and control groups was statistically significant (p<0.001). Conclusions: CORM-3 ameliorates IRI by decreasing apoptosis and may be a novel strategy for protection against renal warm IRI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Urological Association | - |
dc.relation.isPartOf | INVESTIGATIVE AND CLINICAL UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Carbon monoxide-releasing molecule-3: Amelioration of renal ischemia reperfusion injury in a rat model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Dae Keun Kim | - |
dc.contributor.googleauthor | Su-Jin Shin | - |
dc.contributor.googleauthor | Jiyoung Lee | - |
dc.contributor.googleauthor | Sung Yul Park | - |
dc.contributor.googleauthor | Yong Tae Kim | - |
dc.contributor.googleauthor | Hong Yong Choi | - |
dc.contributor.googleauthor | Young Eun Yoon | - |
dc.contributor.googleauthor | Hong Sang Moon | - |
dc.identifier.doi | 10.4111/icu.2020.61.4.441 | - |
dc.contributor.localId | A04596 | - |
dc.relation.journalcode | J01185 | - |
dc.identifier.eissn | 2466-054X | - |
dc.identifier.pmid | 32666002 | - |
dc.subject.keyword | Carbon monoxide | - |
dc.subject.keyword | Ischemia | - |
dc.subject.keyword | Kidney diseases | - |
dc.contributor.alternativeName | Shin, Su Jin | - |
dc.contributor.affiliatedAuthor | 신수진 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 441 | - |
dc.citation.endPage | 451 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE AND CLINICAL UROLOGY, Vol.61(4) : 441-451, 2020-07 | - |
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