Cited 6 times in
Lewis Antigen Phenotype and Survival of Patients With Pancreatic Cancer
DC Field | Value | Language |
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dc.contributor.author | 김광준 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 정문재 | - |
dc.date.accessioned | 2020-12-11T07:52:51Z | - |
dc.date.available | 2020-12-11T07:52:51Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0885-3177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180695 | - |
dc.description.abstract | Objectives: The association of Lewis antigen phenotype with survival of patients with pancreatic ductal adenocarcinoma was investigated. Methods: A total of 1187 patients diagnosed with pancreatic ductal adenocarcinoma were evaluated in a prospective cohort. Patients were classified into 3 different groups according to Lewis antigen phenotype: Lewis antigen (1) A positive [Le(a+b-)], (2) B positive [Le(a-b+)], and (3) negative [Le(a-b-)]. Risk of mortality was analyzed with Cox regression after adjusting for other predictors. Results: The risk of mortality increased in the order of Le(a+b-), Le(a-b+), and Le(a-b-) [reference; hazard ratio (HR), 1.27; 95% confidence interval (CI)], 1.03-1.57; P = 0.02; and HR, 1.65; 95% CI, 1.31-2.09; P < 0.001] after adjusting for other predictors. Among patients with serum carbohydrate antigen (CA) 19-9 lower than 37 U/mL, the association seemed more apparent (reference; HR, 1.50; 95% CI, 0.77-2.29; P = 0.22; and HR, 2.10; 95% CI, 1.10-4.02; P < 0.02). Conclusions: The risk of mortality increased in the order of Le(a+b-), Le(a-b+), and Le(a-b-). The difference in prognosis according to the Lewis antigen phenotype was more pronounced in the low CA 19-9 group, which suggests that the Lewis antigen phenotype works as a biomarker predicting the prognosis of patients with pancreatic cancer with undetectable CA 19-9 level. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Lewis Antigen Phenotype and Survival of Patients With Pancreatic Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sohee Kwon | - |
dc.contributor.googleauthor | Sungsoo Kim | - |
dc.contributor.googleauthor | Edward L Giovannucci | - |
dc.contributor.googleauthor | Manuel Hidalgo | - |
dc.contributor.googleauthor | Mia K Markey | - |
dc.contributor.googleauthor | Alan C Bovik | - |
dc.contributor.googleauthor | Man Jae Kwon | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Hyungsoon Im | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.identifier.doi | 10.1097/MPA.0000000000001687 | - |
dc.contributor.localId | A00317 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03602 | - |
dc.relation.journalcode | J02463 | - |
dc.identifier.eissn | 1536-4828 | - |
dc.identifier.pmid | 33122524 | - |
dc.identifier.url | https://journals.lww.com/pancreasjournal/Fulltext/2020/11000/Lewis_Antigen_Phenotype_and_Survival_of_Patients.13.aspx | - |
dc.contributor.alternativeName | Kim, Kwang Joon | - |
dc.contributor.affiliatedAuthor | 김광준 | - |
dc.contributor.affiliatedAuthor | 박승우 | - |
dc.contributor.affiliatedAuthor | 박정엽 | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.contributor.affiliatedAuthor | 송시영 | - |
dc.contributor.affiliatedAuthor | 정문재 | - |
dc.citation.volume | 49 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1348 | - |
dc.citation.endPage | 1354 | - |
dc.identifier.bibliographicCitation | PANCREAS, Vol.49(10) : 1348-1354, 2020-11 | - |
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