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FEF 25-75% Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease

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dc.contributor.author권도선-
dc.contributor.author김형중-
dc.contributor.author박혜정-
dc.contributor.author변민광-
dc.contributor.author최용준-
dc.date.accessioned2020-12-11T07:51:36Z-
dc.date.available2020-12-11T07:51:36Z-
dc.date.issued2020-11-
dc.identifier.issn1176-9106-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180689-
dc.description.abstractPurpose: The forced mid-expiratory flow (FEF25-75%) value is a potentially sensitive marker of obstructive peripheral airflow. We aimed to assess whether FEF25-75% can be an early predictor of chronic obstructive pulmonary disease (COPD). Patients and methods: Between July 1, 2007 and June 31, 2009, we identified 3624 patients who underwent a pulmonary function test (PFT) in Gangnam Severance Hospital. We selected 307 patients aged over 40 years without COPD who had normal PFT results at baseline and who had follow-up PFT records more than 1 year later. A FEF25-75% z-score less than -0.8435 was considered low. We defined COPD as a forced expiratory volume in one second/forced vital capacity value of less than 0.7 before July 31, 2019. Results: Among 307 patients, 91 (29.6%) had low FEF25-75% at baseline. After 10 years, the incidence rate of COPD in the low FEF25-75% group was significantly higher than that in the normal FEF25-75% group (41.8% vs 7.4%; P-value<0.001). The Cox proportional hazard model showed that age (hazard ratio [HR] 1.09; P-value<0.001), smoking status (occasional smoker HR, 4.59; P-value<0.001 and long-term smoker HR, 2.18; P-value=0.023), and low FEF25-75% (HR, 3.31; P-value<0.001) were predictive factors for the development of COPD. Conclusion: The FEF25-75% value in patients with normal lung function is a useful predictor for the development of COPD. We should carefully monitor patients who present with low FEF25-75% values, even if they have normal lung function.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherDOVE Medical Press-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFEF 25-75% Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDo Sun Kwon-
dc.contributor.googleauthorYong Jun Choi-
dc.contributor.googleauthorTae Hee Kim-
dc.contributor.googleauthorMin Kwang Byun-
dc.contributor.googleauthorJae Hwa Cho-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorHye Jung Park-
dc.identifier.doi10.2147/COPD.S261732-
dc.contributor.localIdA05817-
dc.contributor.localIdA01158-
dc.contributor.localIdA01769-
dc.contributor.localIdA01848-
dc.relation.journalcodeJ01095-
dc.identifier.eissn1178-2005-
dc.identifier.pmid33209020-
dc.subject.keywordCOPD-
dc.subject.keywordrespiratory function tests-
dc.subject.keywordtobacco-
dc.contributor.alternativeNameKwon, Do Sun-
dc.contributor.affiliatedAuthor권도선-
dc.contributor.affiliatedAuthor김형중-
dc.contributor.affiliatedAuthor박혜정-
dc.contributor.affiliatedAuthor변민광-
dc.citation.volume15-
dc.citation.startPage2913-
dc.citation.endPage2921-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol.15 : 2913-2921, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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