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Bioresorbable magnesium-reinforced PLA membrane for guided bone/tissue regeneration

DC FieldValueLanguage
dc.contributor.author권재성-
dc.contributor.author김광만-
dc.date.accessioned2020-12-11T07:46:08Z-
dc.date.available2020-12-11T07:46:08Z-
dc.date.issued2020-12-
dc.identifier.issn1751-6161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180649-
dc.description.abstractConsidering the inferior mechanical properties of the current bioresorbable polymers, a novel bioresorbable magnesium-reinforced polylactide (PLA) membrane was designed for the application in critical defect sites in guided bone/tissue regeneration. The PLA-FAZ91 membrane was fabricated by combining two PLA membranes with a fluoride-coated AZ91 (9 wt% Al, 1 wt% Zn) (FAZ91) magnesium alloy core by hot pressing. A combined double-layered PLA membrane was used as the control group. A three-point bending test was performed to compare their maximum load and stiffness. Samples were immersed in the HBSS for 20 weeks, and their weight loss percentages were recorded, and a three-point bending test was performed after immersion. An ion release test was performed by immersing samples in the HBSS for 4 weeks and determining the pH and ion concentrations of the HBSS. Cell viability was tested by culturing pre-osteoblast cells with sample extracts in the culture medium obtained from degraded samples. As a result, PLA-FAZ91 showed a significantly higher maximum load and stiffness than those of the non-reinforced PLA membrane. The weight loss of PLA-FAZ91 was much faster, as FAZ91 showed major degradation and was completely degraded after 16-20 weeks of immersion. The degradation of the PLA wrap was accelerated by FAZ91. The mechanical superiority of PLA-FAZ91 over PLA endured for at least 3 weeks during immersion. The pH, magnesium- and fluoride-ion concentration in the PLA-FAZ91 group increased at an appropriate rate. The cell viability was not adversely affected by the addition of FAZ91 to PLA. Therefore, the bioresorbable magnesium-reinforced PLA membrane has the potential to be used as a good alternative to pure PLA membrane in guided bone/tissue regeneration.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBioresorbable magnesium-reinforced PLA membrane for guided bone/tissue regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorHao Yang Zhang-
dc.contributor.googleauthorHeng Bo Jiang-
dc.contributor.googleauthorJi-Eun Kim-
dc.contributor.googleauthorShuXin Zhang-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorJae-Sung Kwon-
dc.identifier.doi10.1016/j.jmbbm.2020.104061-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.contributor.localIdA00312-
dc.relation.journalcodeJ03939-
dc.identifier.eissn1878-0180-
dc.identifier.pmid32889335-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S175161612030610X-
dc.subject.keywordBioresorbable membrane-
dc.subject.keywordGuided bone regeneration-
dc.subject.keywordGuided tissue regeneration-
dc.subject.keywordMagnesium alloy-
dc.subject.keywordPolylactide-
dc.subject.keywordReinforced membrane-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김광만-
dc.citation.volume112-
dc.citation.startPage104061-
dc.identifier.bibliographicCitationJOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol.112 : 104061, 2020-12-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

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