Cited 4 times in
Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations
DC Field | Value | Language |
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dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2020-12-08T01:51:55Z | - |
dc.date.available | 2020-12-08T01:51:55Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180633 | - |
dc.description.abstract | Objectives: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. Methods: We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). Results: We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: -2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39-2.85) compared with men (OR, 1.33; 95% CI, 1.10-1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86-12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m2, individuals with a CG/GG genotype and BMI ≥25.69 kg/m2 had an OR (95% CI) of 2.61 (1.97-3.47). Conclusions: These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | Journal of Lipid and Atherosclerosis | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Jae Woong Sull | - |
dc.contributor.googleauthor | Soriul Kim | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.identifier.doi | 10.12997/jla.2019.8.2.252 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J01562 | - |
dc.identifier.eissn | 2288-2561 | - |
dc.identifier.pmid | 32821715 | - |
dc.subject.keyword | Cholesterol ester transfer proteins | - |
dc.subject.keyword | Genetic polymorphisms | - |
dc.subject.keyword | HDL cholesterol | - |
dc.subject.keyword | Physical activity | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | 지선하 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 252 | - |
dc.citation.endPage | 257 | - |
dc.identifier.bibliographicCitation | Journal of Lipid and Atherosclerosis, Vol.8(2) : 252-257, 2019-09 | - |
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