129 216

Cited 0 times in

Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations

DC Field Value Language
dc.contributor.author지선하-
dc.date.accessioned2020-12-08T01:51:55Z-
dc.date.available2020-12-08T01:51:55Z-
dc.date.issued2019-09-
dc.identifier.issn2287-2892-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180633-
dc.description.abstractObjectives: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. Methods: We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). Results: We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: -2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39-2.85) compared with men (OR, 1.33; 95% CI, 1.10-1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86-12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m2, individuals with a CG/GG genotype and BMI ≥25.69 kg/m2 had an OR (95% CI) of 2.61 (1.97-3.47). Conclusions: These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher한국지질동맥경화학회-
dc.relation.isPartOfJournal of Lipid and Atherosclerosis-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorJae Woong Sull-
dc.contributor.googleauthorSoriul Kim-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.12997/jla.2019.8.2.252-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ01562-
dc.identifier.eissn2288-2561-
dc.identifier.pmid32821715-
dc.subject.keywordCholesterol ester transfer proteins-
dc.subject.keywordGenetic polymorphisms-
dc.subject.keywordHDL cholesterol-
dc.subject.keywordPhysical activity-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume8-
dc.citation.number2-
dc.citation.startPage252-
dc.citation.endPage257-
dc.identifier.bibliographicCitationJournal of Lipid and Atherosclerosis, Vol.8(2) : 252-257, 2019-09-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.