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Pathology of C3 Glomerulopathy

Authors
 Su-Jin Shin  ;  Yoonje Seong  ;  Beom Jin Lim 
Citation
 Childhood Kidney Diseases, Vol.23(2) : 93-99, 2019-10 
Journal Title
 Childhood Kidney Diseases 
ISSN
 2384-0250 
Issue Date
2019-10
Keywords
C3 glomerulopathy ; C3 glomerulonephritis ; Membranoproliferative glomerulonephritis ; Dense deposit disease ; Alternative complement pathway
Abstract
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.
Files in This Item:
T201906623.pdf Download
DOI
10.3339/jkspn.2019.23.2.93
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shin, Su Jin(신수진) ORCID logo https://orcid.org/0000-0001-9114-8438
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180626
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