405 58

Cited 0 times in

Cytoreductive Nephrectomy in Metastatic Papillary Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium

DC FieldValueLanguage
dc.contributor.author라선영-
dc.date.accessioned2020-12-08T01:51:10Z-
dc.date.available2020-12-08T01:51:10Z-
dc.date.issued2019-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180624-
dc.description.abstractBackground: There is evidence that cytoreductive nephrectomy (CN) may be beneficial in metastatic renal cell carcinoma (mRCC). This has been studied predominantly in clear-cell RCC, with more limited data on the role of CN in patients with papillary histology. Objective: To determine the benefit of CN in synchronous metastatic papillary RCC. Design, setting, and participants: Using the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) database, a retrospective analysis was performed for patients with papillary mRCC treated with or without CN. Outcome measurements and statistical analysis: Median overall survival (OS) and progression-free survival (PFS) were determined for both patient groups. Cox regression analysis was performed to control for imbalances in individual IMDC risk factors. Results and limitations: In total, 647 patients with papillary mRCC were identified, of whom 353 had synchronous metastatic disease. Of these, 109 patients were treated with CN and 244 were not. The median follow-up was 57.1mo (95% confidence interval [CI] 32.9-77.8) and the OS from the start of first-line targeted therapy for the entire cohort was 13.2mo (95% CI 12.0-16.1). Median OS for patients with CN was 16.3mo, compared to 8.6mo (p<0.0001) in the no-CN group. When adjusted for individual IMDC risk factors, the hazard ratio (HR) of death for CN was 0.62 (95% CI 0.45-0.85; p=0.0031). Limitations include the retrospective nature of the analysis. Conclusions: The use of CN in patients with mRCC and papillary histology appears to be associated with better survival compared to no CN after adjustment for risk criteria. Selection of appropriate candidates for CN is crucial. A clinical trial in this rare population may not be possible. Patient summary: In a population of patients with advanced papillary kidney cancer, we found that surgical removal of the primary kidney tumor was associated with better overall survival.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfEUROPEAN UROLOGY ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Renal Cell / mortality-
dc.subject.MESHCarcinoma, Renal Cell / pathology-
dc.subject.MESHCarcinoma, Renal Cell / surgery*-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNephrectomy / methods*-
dc.subject.MESHProgression-Free Survival-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.titleCytoreductive Nephrectomy in Metastatic Papillary Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJeffrey Graham-
dc.contributor.googleauthorJ Connor Wells-
dc.contributor.googleauthorFrede Donskov-
dc.contributor.googleauthorJae Lyun Lee-
dc.contributor.googleauthorAnna Fraccon-
dc.contributor.googleauthorFelice Pasini-
dc.contributor.googleauthorCamillo Porta-
dc.contributor.googleauthorI Alex Bowman-
dc.contributor.googleauthorGeorg A Bjarnason-
dc.contributor.googleauthorD Scott Ernst-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorBenoit Beuselinck-
dc.contributor.googleauthorAaron Hansen-
dc.contributor.googleauthorScott A North-
dc.contributor.googleauthorChristian K Kollmannsberger-
dc.contributor.googleauthorLori A Wood-
dc.contributor.googleauthorUlka N Vaishampayan-
dc.contributor.googleauthorSumanta K Pal-
dc.contributor.googleauthorToni K Choueiri-
dc.contributor.googleauthorDaniel Y C Heng-
dc.identifier.doi10.1016/j.euo.2019.03.007-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ03956-
dc.identifier.eissn2588-9311-
dc.identifier.pmid31411994-
dc.subject.keywordCytoreductive nephrectomy-
dc.subject.keywordKidney cancer-
dc.subject.keywordMetastatic renal cell carcinoma-
dc.subject.keywordPapillary-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.affiliatedAuthor라선영-
dc.citation.volume2-
dc.citation.number6-
dc.citation.startPage643-
dc.citation.endPage648-
dc.identifier.bibliographicCitationEUROPEAN UROLOGY ONCOLOGY, Vol.2(6) : 643-648, 2019-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.