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Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study

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dc.contributor.author지선하-
dc.date.accessioned2020-12-01T18:07:26Z-
dc.date.available2020-12-01T18:07:26Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180613-
dc.description.abstractSmoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions are expected to affect COPD onset. We aimed to identify the common genetic variants interacting with pack-years of smoking on FEV1/FVC ratios in individuals with normal lung function. A genome-wide interaction study (GWIS) on FEV1/FVC was performed for individuals with FEV1/FVC ratio ≥ 70 in the Korea Associated Resource cohort data, and significant SNPs were validated using data from two other Korean cohorts. The GWIS revealed that rs10947231 and rs8192575 met genome-wide significant levels; For [Formula: see text] the likelihood ratio (LR) test was conducted, and its P values, PLR, for rs10947231 and rs8192575 were 2.23 × 10-12 and 1.18 × 10-8, respectively. Interaction between rs8192575 and smoking is significantly replicated with two additional data (PINT = 0.0454, 0.0131). Expression quantitative trait loci, topologically associated domains, and PrediXcan analyses revealed that rs8192575 is significantly associated with AGER expression. SNPs on the 6p21 region are associated with FEV1/FVC, and the effect of smoking on FEV1/FVC differs among the associated genotypes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorBoram Park-
dc.contributor.googleauthorJaehoon An-
dc.contributor.googleauthorWonji Kim-
dc.contributor.googleauthorHae Yeon Kang-
dc.contributor.googleauthorSang Baek Koh-
dc.contributor.googleauthorBermseok Oh-
dc.contributor.googleauthorKeum Ji Jung-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorWoo Jin Kim-
dc.contributor.googleauthorMichael H Cho-
dc.contributor.googleauthorEdwin K Silverman-
dc.contributor.googleauthorTaesung Park-
dc.contributor.googleauthorSungho Won-
dc.identifier.doi10.1038/s41598-020-70092-0-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32753590-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage13075-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 13075, 2020-08-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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