Cited 12 times in
Aggregation-driven fluorescence quenching of imidazole-functionalized perylene diimide for urea sensing
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2020-12-01T18:07:22Z | - |
dc.date.available | 2020-12-01T18:07:22Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0003-2654 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180612 | - |
dc.description.abstract | Stimuli-responsive self-assembly of functional amphiphilic molecules by specific chemical stimulants is a promising strategy for sensor application. Herein, we demonstrate a fast optical detection of urea in human urine by exploiting bolaform perylene diimide functionalized with imidazoles (PDI-Hm), whose aggregation is induced by urea hydrolysis. The hydroxides produced from the enzymatic urea hydrolysis deprotonate the imidazoles to reduce electrostatic repulsion between PDI-Hm molecules in a HCl-methanol mixture, thereby leading to aggregation and consequent fluorescence quenching. The molecular interaction of PDI-Hm was further scrutinized to understand the aggregation behavior driven by the screening of electrical repulsion. As an optical sensing probe, PDI-Hm displays a prompt response (<1 min) to hydroxide and detection limit of 0.4 mM for urea. PDI-Hm incorporating urease offers considerable selectivity toward urea among various components in human urine. The urea sensing accuracy of this PDI-Hm fluorescence chemosensor is comparable to that of a clinical method, showing 93.4% consistency. Furthermore, the PDI-Hm was fabricated into a gel film allowed for the fast screening of excessive urea in urine. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isPartOf | ANALYST | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Aggregation-driven fluorescence quenching of imidazole-functionalized perylene diimide for urea sensing | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Junghyun Cho | - |
dc.contributor.googleauthor | Changjoon Keum | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Sang-Yup Lee | - |
dc.identifier.doi | 10.1039/d0an01252a | - |
dc.contributor.localId | A02810 | - |
dc.relation.journalcode | J00130 | - |
dc.identifier.eissn | 1364-5528 | - |
dc.identifier.pmid | 32902520 | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2020/AN/D0AN01252A#!divAbstract | - |
dc.contributor.alternativeName | Lee, Sang Guk | - |
dc.contributor.affiliatedAuthor | 이상국 | - |
dc.citation.volume | 145 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 7312 | - |
dc.citation.endPage | 7319 | - |
dc.identifier.bibliographicCitation | ANALYST, Vol.145(22) : 7312-7319, 2020-11 | - |
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