Cited 19 times in
In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2020-12-01T18:05:29Z | - |
dc.date.available | 2020-12-01T18:05:29Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180591 | - |
dc.description.abstract | This study investigates GT-1 (also known as LCB10-0200), a novel-siderophore cephalosporin, inhibited multidrug-resistant (MDR) Gram-negative pathogen, via a Trojan horse strategy exploiting iron-uptake systems. We investigated GT-1 activity and the role of siderophore uptake systems, and the combination of GT-1 and a non-β-lactam β-lactamase inhibitor (BLI) of diazabicyclooctane, GT-055, (also referred to as LCB18-055) against molecularly characterised resistant Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. isolates. GT-1 and GT-1/GT-055 were tested in vitro against comparators among three different characterised panel strain sets. Bacterial resistome and siderophore uptake systems were characterised to elucidate the genetic basis for GT-1 minimum inhibitory concentrations (MICs). GT-1 exhibited in vitro activity (≤2 μg/mL MICs) against many MDR isolates, including extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing E. coli and K. pneumoniae and oxacillinase (OXA)-producing Acinetobacter spp. GT-1 also inhibited strains with mutated siderophore transporters and porins. Although BLI GT-055 exhibited intrinsic activity (MIC 2-8 μg/mL) against most E. coli and K. pneumoniae isolates, GT-055 enhanced the activity of GT-1 against many GT-1-resistant strains. Compared with CAZ-AVI, GT-1/GT-055 exhibited lower MICs against E. coli and K. pneumoniae isolates. GT-1 demonstrated potent in vitro activity against clinical panel strains of E. coli, K. pneumoniae and Acinetobacter spp. GT-055 enhanced the in vitro activity of GT-1 against many GT-1-resistant strains. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Le Phuong Nguyen | - |
dc.contributor.googleauthor | Naina Adren Pinto | - |
dc.contributor.googleauthor | Thao Nguyen Vu | - |
dc.contributor.googleauthor | Hyunsook Lee | - |
dc.contributor.googleauthor | Young Lag Cho | - |
dc.contributor.googleauthor | Jung-Hyun Byun | - |
dc.contributor.googleauthor | Roshan D'Souza | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.identifier.doi | 10.3390/antibiotics9050267 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J03862 | - |
dc.identifier.eissn | 2079-6382 | - |
dc.identifier.pmid | 32443875 | - |
dc.subject.keyword | GT-055 | - |
dc.subject.keyword | GT-1 | - |
dc.subject.keyword | siderophore-cephalosporin | - |
dc.subject.keyword | β-lactamase inhibitor | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 267 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, Vol.9(5) : 267, 2020-05 | - |
dc.identifier.rimsid | 67390 | - |
dc.type.rims | ART | - |
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