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In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains

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dc.contributor.author용동은-
dc.date.accessioned2020-12-01T18:05:29Z-
dc.date.available2020-12-01T18:05:29Z-
dc.date.issued2020-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180591-
dc.description.abstractThis study investigates GT-1 (also known as LCB10-0200), a novel-siderophore cephalosporin, inhibited multidrug-resistant (MDR) Gram-negative pathogen, via a Trojan horse strategy exploiting iron-uptake systems. We investigated GT-1 activity and the role of siderophore uptake systems, and the combination of GT-1 and a non-β-lactam β-lactamase inhibitor (BLI) of diazabicyclooctane, GT-055, (also referred to as LCB18-055) against molecularly characterised resistant Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. isolates. GT-1 and GT-1/GT-055 were tested in vitro against comparators among three different characterised panel strain sets. Bacterial resistome and siderophore uptake systems were characterised to elucidate the genetic basis for GT-1 minimum inhibitory concentrations (MICs). GT-1 exhibited in vitro activity (≤2 μg/mL MICs) against many MDR isolates, including extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing E. coli and K. pneumoniae and oxacillinase (OXA)-producing Acinetobacter spp. GT-1 also inhibited strains with mutated siderophore transporters and porins. Although BLI GT-055 exhibited intrinsic activity (MIC 2-8 μg/mL) against most E. coli and K. pneumoniae isolates, GT-055 enhanced the activity of GT-1 against many GT-1-resistant strains. Compared with CAZ-AVI, GT-1/GT-055 exhibited lower MICs against E. coli and K. pneumoniae isolates. GT-1 demonstrated potent in vitro activity against clinical panel strains of E. coli, K. pneumoniae and Acinetobacter spp. GT-055 enhanced the in vitro activity of GT-1 against many GT-1-resistant strains.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.relation.isPartOfANTIBIOTICS-BASEL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIn Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorLe Phuong Nguyen-
dc.contributor.googleauthorNaina Adren Pinto-
dc.contributor.googleauthorThao Nguyen Vu-
dc.contributor.googleauthorHyunsook Lee-
dc.contributor.googleauthorYoung Lag Cho-
dc.contributor.googleauthorJung-Hyun Byun-
dc.contributor.googleauthorRoshan D'Souza-
dc.contributor.googleauthorDongeun Yong-
dc.identifier.doi10.3390/antibiotics9050267-
dc.contributor.localIdA02423-
dc.relation.journalcodeJ03862-
dc.identifier.eissn2079-6382-
dc.identifier.pmid32443875-
dc.subject.keywordGT-055-
dc.subject.keywordGT-1-
dc.subject.keywordsiderophore-cephalosporin-
dc.subject.keywordβ-lactamase inhibitor-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.affiliatedAuthor용동은-
dc.citation.volume9-
dc.citation.number5-
dc.citation.startPage267-
dc.identifier.bibliographicCitationANTIBIOTICS-BASEL, Vol.9(5) : 267, 2020-05-
dc.identifier.rimsid67390-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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