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Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

DC FieldValueLanguage
dc.contributor.author김호성-
dc.contributor.author채현욱-
dc.date.accessioned2020-12-01T18:04:34Z-
dc.date.available2020-12-01T18:04:34Z-
dc.date.issued2020-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180581-
dc.description.abstractBackground: The incidence of precocious puberty has increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals including agricultural pesticides has been a subject of global study, but human data are lacking. Purpose: We investigated the relationship between agricultural pesticides and the development of precocious puberty. Methods: We enrolled 60 female subjects at Severance Children's Hospital from December 2015 to January 2017. Of them, 30 were diagnosed with precocious puberty, while the other 30 prepubertal girls were enrolled as normal controls. We investigated their clinical characteristics and analyzed the urinary levels of 320 different agricultural pesticides. Results: Agricultural pesticide was detected in one of 30 patients with precocious puberty (3.3%) versus 2 of 30 girls in the normal control group (3.3% vs. 6.7%, P=0.554). Dinotefuran, a neonicotinoid-class insecticide, was detected in the samples of all 3 positive subjects. Conclusion: Our results showed no relationship between agricultural pesticides and the development of precocious puberty. Larger sample sizes and robustly controlled variables are necessary to further investigate this topic.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Pediatric Society-
dc.relation.isPartOfClinical and Experimental Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of agricultural pesticide on precocious puberty in urban children: an exploratory study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJunghwan Suh-
dc.contributor.googleauthorHan Saem Choi-
dc.contributor.googleauthorAhreum Kwon-
dc.contributor.googleauthorHyun Wook Chae-
dc.contributor.googleauthorHo-Seong Kim-
dc.identifier.doi10.3345/cep.2019.00416-
dc.contributor.localIdA01184-
dc.contributor.localIdA04026-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ03867-
dc.identifier.eissn2713-4148-
dc.identifier.pmid32024321-
dc.subject.keywordAgricultural pesticide-
dc.subject.keywordEndocrine disrupting chemicals-
dc.subject.keywordPrecocious puberty-
dc.contributor.alternativeNameKim, Ho Seong-
dc.contributor.affiliatedAuthor김호성-
dc.contributor.affiliatedAuthor채현욱-
dc.contributor.affiliatedAuthor채현욱-
dc.citation.volume63-
dc.citation.number4-
dc.citation.startPage146-
dc.citation.endPage150-
dc.identifier.bibliographicCitationClinical and Experimental Pediatrics, Vol.63(4) : 146-150, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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