0 305

Cited 0 times in

Targeting inducible costimulator expressed on CXCR5 + PD-1 + T H cells suppresses the progression of pemphigus vulgaris

DC Field Value Language
dc.contributor.author김수찬-
dc.contributor.author김종훈-
dc.date.accessioned2020-12-01T18:03:47Z-
dc.date.available2020-12-01T18:03:47Z-
dc.date.issued2020-11-
dc.identifier.issn0091-6749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180573-
dc.description.abstractBackground: Pemphigus vulgaris (PV) is an autoimmune bullous disease mediated by autoantibodies against desmoglein 3 (DSG3). Inducible costimulator (ICOS) is a costimulatory receptor expressed on T cells and influences the activity of T follicular helper (TFH) cells in various autoimmune diseases, but the roles of ICOS and TFH cells in PV remain unclear. Objective: We examined the immunological characteristics, antigen specificity, and pathogenicity of CD4+ T-cell subpopulations, as well as the therapeutic effect of anti-ICOS blocking antibodies in PV. Methods: A mouse model of PV was established by adoptive transfer of immune cells from the skin-draining lymph nodes or spleens of DSG3-expressing skin-grafted Dsg3-/- mice into Rag1-/- mice. The TFH cells and CD4+ T cells in PBMCs from PV patients were examined by flow cytometry. Results: Among CD4+ T cells from the mouse model, ICOS-positive TFH cells were associated with B-cell differentiation and were required for disease induction. Using an MHC class II tetramer, DSG3-specific ICOS+ TFH cells were found to be associated with anti-DSG3 antibody production and expanded in the absence of B cells. In human PV, the frequency of ICOS+CXCR5+PD-1+ memory CD4+ T cells correlated with the autoantibody level. Treatment with anti-ICOS blocking antibodies targeting ICOS+ TFH cells decreased the anti-DSG3 antibody level and delayed disease progression in vivo. Conclusions: Mouse Dsg3-specific ICOS+ TFH cells and human ICOS+CXCR5+PD-1+ TH cells are associated with the anti-DSG3 antibody response in PV. ICOS expressed on CXCR5+PD-1+ TH cells may be a therapeutic target for PV.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSt Louis, Mosby-
dc.relation.isPartOfJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTargeting inducible costimulator expressed on CXCR5 + PD-1 + T H cells suppresses the progression of pemphigus vulgaris-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorA Reum Kim-
dc.contributor.googleauthorDawoon Han-
dc.contributor.googleauthorJi Young Choi-
dc.contributor.googleauthorJoon Seok-
dc.contributor.googleauthorSong-Ee Kim-
dc.contributor.googleauthorSeong-Hoon Seo-
dc.contributor.googleauthorHayato Takahashi-
dc.contributor.googleauthorMasayuki Amagai-
dc.contributor.googleauthorSu-Hyung Park-
dc.contributor.googleauthorSoo-Chan Kim-
dc.contributor.googleauthorEui-Cheol Shin-
dc.contributor.googleauthorJong Hoon Kim-
dc.identifier.doi10.1016/j.jaci.2020.03.036-
dc.contributor.localIdA00637-
dc.contributor.localIdA05233-
dc.relation.journalcodeJ01228-
dc.identifier.eissn1097-6825-
dc.identifier.pmid32311391-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0091674920304930-
dc.subject.keywordT follicular helper cell-
dc.subject.keyworddesmoglein-
dc.subject.keywordhumoral immunity-
dc.subject.keywordinducible costimulator-
dc.subject.keywordpemphigus vulgaris-
dc.contributor.alternativeNameKim, Soo Chan-
dc.contributor.affiliatedAuthor김수찬-
dc.contributor.affiliatedAuthor김종훈-
dc.citation.volume146-
dc.citation.number5-
dc.citation.startPage1070-
dc.citation.endPage1079.e8-
dc.identifier.bibliographicCitationJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.146(5) : 1070-1079.e8, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.