Cited 7 times in
Risk of invasive pneumococcal disease in patients with asplenia/hyposplenism: A nationwide population-based study in Korea, 2009-2018
DC Field | Value | Language |
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dc.contributor.author | 강지만 | - |
dc.contributor.author | 안종균 | - |
dc.contributor.author | 인경 | - |
dc.contributor.author | 정인경 | - |
dc.contributor.author | 한민경 | - |
dc.date.accessioned | 2020-12-01T17:54:07Z | - |
dc.date.available | 2020-12-01T17:54:07Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180502 | - |
dc.description.abstract | Objectives: We aimed to determine the incidence and relative risk (RR) of invasive pneumococcal disease (IPD) in patients with asplenia/hyposplenism, using a nationwide population-based database. Methods: From 2009 to 2018, all claimed cases of newly diagnosed asplenia/hyposplenism in the National Health Insurance Service in South Korea were included. The incidence and RR of IPD in asplenia/hyposplenism patients were investigated using the Korean Center for Disease Control criteria. Results: Fifty-seven IPD cases were identified among 21,376 patients with 82,748 person-years of exposure. The cumulative 8-year IPD incidence was 0.5%; 45.6% of the infections occurred within two years after an asplenia/hyposplenism diagnosis. The age-standardised incidence rate was 104.5 per 100,000 person-years (95% confidence interval [CI], 103.6-105.4). Patients aged <5 years had a 15.1-times higher risk of IPD than those aged ≥60 years (95% CI: 5.8-39.5, p < 0.0001). The RR of IPD was 32.0 times higher in patients with asplenia/hyposplenism than in the general population (95% CI, 21.7-47.0); the standardized incidence ratio was 17.9(95% CI, 11.8-26.0). Conclusions: This large population-based study highlights the high IPD incidence rate and RR in Korean patients with asplenia/hyposplenism. Increased awareness and effective prevention strategies are needed for these high-risk populations, especially children aged <5 years. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Risk of invasive pneumococcal disease in patients with asplenia/hyposplenism: A nationwide population-based study in Korea, 2009-2018 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Ji-Man Kang | - |
dc.contributor.googleauthor | Eun Hwa Kim | - |
dc.contributor.googleauthor | Kyong Ihn | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Minkyung Han | - |
dc.contributor.googleauthor | Jong Gyun Ahn | - |
dc.identifier.doi | 10.1016/j.ijid.2020.07.013 | - |
dc.contributor.localId | A05720 | - |
dc.contributor.localId | A02261 | - |
dc.contributor.localId | A05505 | - |
dc.contributor.localId | A03693 | - |
dc.contributor.localId | A05436 | - |
dc.relation.journalcode | J01125 | - |
dc.identifier.eissn | 1878-3511 | - |
dc.identifier.pmid | 32663603 | - |
dc.subject.keyword | Asplenia | - |
dc.subject.keyword | Invasive pneumococcal disease | - |
dc.subject.keyword | Population-based study | - |
dc.subject.keyword | Relative risk | - |
dc.subject.keyword | Splenectomy | - |
dc.contributor.alternativeName | Kang, Ji-Man | - |
dc.contributor.affiliatedAuthor | 강지만 | - |
dc.contributor.affiliatedAuthor | 안종균 | - |
dc.contributor.affiliatedAuthor | 인경 | - |
dc.contributor.affiliatedAuthor | 정인경 | - |
dc.contributor.affiliatedAuthor | 한민경 | - |
dc.citation.volume | 98 | - |
dc.citation.startPage | 486 | - |
dc.citation.endPage | 493 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.98 : 486-493, 2020-09 | - |
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