Cited 5 times in
Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 이민영 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2020-12-01T17:53:55Z | - |
dc.date.available | 2020-12-01T17:53:55Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180501 | - |
dc.description.abstract | Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely prescribed for type 2 diabetes (T2D) and their glycemic control effects are well studied. However, information regarding the effects of switching DPP-4 inhibitors is limited, especially in older patients. Research design and methods: We investigated whether switching from linagliptin to teneligliptin decreases blood glucose in older (≥65 years) T2D patients. In total, 164 patients with T2D who switched from linagliptin to teneligliptin for >12 weeks were included and the primary outcome was glycemic changes. Results: Switching from linagliptin to teneligliptin ameliorated fasting blood glucose (148.1 ± 47.1 to 139.6 ± 43.4 mg/dL), glycated hemoglobin (HbA1c; 7.9 ± 1.3 to 7.5 ± 1.2%), and postprandial blood glucose (224.8 ± 77.4 to 205.8 ± 70.8 mg/dL) levels (all P < 0.05). Low-density lipoprotein cholesterol concentration was reduced while liver and kidney functions were maintained. Subgroup analysis showed that glucose control improved more in patients with uncontrolled hyperglycemia (HbA1c > 8.0%) and chronic kidney disease (estimated glomerular filtration rate <90 mL/min/1.73m2). Multiple logistic analysis indicated higher baseline HbA1c was the strongest predictor of teneligliptin switching response. Conclusion: Switching from linagliptin to teneligliptin helps maintain kidney function and reduce blood glucose safely in older patients with T2D. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Dove Medical Press | - |
dc.relation.isPartOf | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Eugene Han | - |
dc.contributor.googleauthor | Minyoung Lee | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Hye Soon Kim | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.identifier.doi | 10.2147/DMSO.S267994 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A05491 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J03921 | - |
dc.identifier.eissn | 1178-7007 | - |
dc.identifier.pmid | 33173319 | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | dipeptidyl peptidase 4 inhibitor | - |
dc.subject.keyword | linagliptin | - |
dc.subject.keyword | older patients | - |
dc.subject.keyword | teneligliptin | - |
dc.subject.keyword | type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | 강은석 | - |
dc.contributor.affiliatedAuthor | 이민영 | - |
dc.contributor.affiliatedAuthor | 이병완 | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 차봉수 | - |
dc.citation.volume | 2020 | - |
dc.citation.startPage | 4113 | - |
dc.citation.endPage | 4121 | - |
dc.identifier.bibliographicCitation | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, Vol.2020 : 4113-4121, 2020-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.