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Comparison of the outcomes of biliary atresia with cystic degeneration and isolated biliary atresia: A matched-pair analysis

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dc.contributor.author인경-
dc.contributor.author한석주-
dc.contributor.author호인걸-
dc.date.accessioned2020-12-01T17:53:24Z-
dc.date.available2020-12-01T17:53:24Z-
dc.date.issued2020-10-
dc.identifier.issn0022-3468-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180497-
dc.description.abstractBackground: Patients with biliary atresia (BA) with extrahepatic cystic degeneration (BACD) have a unique pathophysiology; however, clinical outcomes and progression of perinatal degeneration are not well-defined. We aimed to investigate the differences in clinical characteristics and outcomes between BACD and isolated BA (IBA). Methods: We performed a retrospective analysis of patients with BA who underwent Kasai portoenterostomy (KPE) from August 1997 to January 2018 and compared the clinical features and outcomes between BACD (n = 21) and IBA (n = 237). Matched-pair analysis for age and sex was performed between BACD and IBA groups to reduce confounding. Results: Before matched-pair analysis, we found that BACD patients were younger at KPE (45 vs. 64 days, p = 0.008), showed lower total bilirubin at the 3-month follow-up (0.5 vs. 1.4 mg/dL, p = 0.002), and higher 5-year native liver survival rate (95.2% vs. 61.4%, p = 0.006) than IBA patients. After matching, the BACD group showed significantly lower total bilirubin levels at the 3-month follow-up (0.5 vs. 1.5 mg/dL, p = 0.036) and higher 5-year native liver survival rate (95.2% vs. 57.5%, p = 0.006) than the IBA group. Conclusion: BACD demonstrated higher bilirubin clearance and native liver survival rates than IBA. Levels of evidence: Treatment Study, Level III.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSaunders-
dc.relation.isPartOfJOURNAL OF PEDIATRIC SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of the outcomes of biliary atresia with cystic degeneration and isolated biliary atresia: A matched-pair analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorKyong Ihn-
dc.contributor.googleauthorIn Geol Ho-
dc.contributor.googleauthorJi Hee Lee-
dc.contributor.googleauthorYounghyun Na-
dc.contributor.googleauthorDongeun Lee-
dc.contributor.googleauthorSeok Joo Han-
dc.identifier.doi10.1016/j.jpedsurg.2020.02.054-
dc.contributor.localIdA05505-
dc.contributor.localIdA04288-
dc.contributor.localIdA04706-
dc.relation.journalcodeJ01689-
dc.identifier.eissn1531-5037-
dc.identifier.pmid32192737-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0022346820301858-
dc.subject.keywordBiliary atresia-
dc.subject.keywordCystic degeneration-
dc.subject.keywordKasai portoenterostomy-
dc.subject.keywordLiver fibrosis-
dc.subject.keywordMatching-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameIhn, Kyong-
dc.contributor.affiliatedAuthor인경-
dc.contributor.affiliatedAuthor한석주-
dc.contributor.affiliatedAuthor호인걸-
dc.citation.volume50-
dc.citation.number10-
dc.citation.startPage2177-
dc.citation.endPage2182-
dc.identifier.bibliographicCitationJOURNAL OF PEDIATRIC SURGERY, Vol.50(10) : 2177-2182, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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