0 316

Cited 8 times in

Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation

DC Field Value Language
dc.contributor.author김경원-
dc.date.accessioned2020-12-01T17:53:13Z-
dc.date.available2020-12-01T17:53:13Z-
dc.date.issued2020-02-
dc.identifier.issn0021-7557-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180495-
dc.description.abstractObjective: Mold exposure in early life may be associated with development of atopic dermatitis; however, studies of this link are inconclusive and evidence for the underlying mechanism(s) is lacking. This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms. Method: The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study (n=1446). Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists. Exposure to mold was assessed by questionnaire. The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation. Results: Prenatal, but not postnatal, mold exposure was significantly associated with atopic dermatitis (adjusted odds ratio, 1.36; 95% confidence interval, 1.01-1.83). Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy (p=0.021). The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants. The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age (r=0.613, p<0.001). Conclusion: Indoor mold exposure during the fetal period is associated with development of atopic dermatitis via IgE-mediated allergic inflammation. Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Editora Ltda-
dc.relation.isPartOfJORNAL DE PEDIATRIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAsthma*-
dc.subject.MESHChild-
dc.subject.MESHCohort Studies-
dc.subject.MESHDermatitis, Atopic* / etiology-
dc.subject.MESHFemale-
dc.subject.MESHFungi-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInflammation / etiology*-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPregnancy-
dc.titlePrenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorEun Lee-
dc.contributor.googleauthorKil Yong Choi-
dc.contributor.googleauthorMi-Jin Kang-
dc.contributor.googleauthorSo-Yeon Lee-
dc.contributor.googleauthorJisun Yoon-
dc.contributor.googleauthorHyun-Ju Cho-
dc.contributor.googleauthorSungsu Jung-
dc.contributor.googleauthorSi Hyeon Lee-
dc.contributor.googleauthorDong In Suh-
dc.contributor.googleauthorYoun Ho Shin-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorKangmo Ahn-
dc.contributor.googleauthorSoo-Jong Hong-
dc.identifier.doi10.1016/j.jped.2018.07.012-
dc.contributor.localIdA00303-
dc.relation.journalcodeJ03933-
dc.identifier.eissn1678-4782-
dc.identifier.pmid30243937-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021755718303735-
dc.subject.keywordAllergic inflammation-
dc.subject.keywordAmbiente-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordDermatite atópica-
dc.subject.keywordEnvironment-
dc.subject.keywordMicrobioma-
dc.subject.keywordMofo-
dc.subject.keywordMold-
dc.subject.keywordMycobiome-
dc.subject.keywordPrenatal-
dc.subject.keywordPré-natal-
dc.subject.keywordReação alérgica-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.affiliatedAuthor김경원-
dc.citation.volume96-
dc.citation.number1-
dc.citation.startPage125-
dc.citation.endPage131-
dc.identifier.bibliographicCitationJORNAL DE PEDIATRIA, Vol.96(1) : 125-131, 2020-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.