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Development of Colonic Organoids Containing Enteric Nerves or Blood Vessels from Human Embryonic Stem Cells

DC Field Value Language
dc.contributor.author용동은-
dc.date.accessioned2020-12-01T17:50:28Z-
dc.date.available2020-12-01T17:50:28Z-
dc.date.issued2020-09-
dc.identifier.issn2073-4409-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180476-
dc.description.abstractThe increased interest in organoid research in recent years has contributed to an improved understanding of diseases that are currently untreatable. Various organoids, including kidney, brain, retina, liver, and spinal cord, have been successfully developed and serve as potential sources for regenerative medicine studies. However, the application of organoids has been limited by their lack of tissue components such as nerve and blood vessels that are essential to organ physiology. In this study, we used three-dimensional co-culture methods to develop colonic organoids that contained enteric nerves and blood vessels. The development of enteric nerves and blood vessels was confirmed phenotypically and genetically by the use of immunofluorescent staining and Western blotting. Colonic organoids that contain essential tissue components could serve as a useful model for the study of colon diseases and help to overcome current bottlenecks in colon disease research.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCELLS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDevelopment of Colonic Organoids Containing Enteric Nerves or Blood Vessels from Human Embryonic Stem Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorChul Soon Park-
dc.contributor.googleauthorLe Phuong Nguyen-
dc.contributor.googleauthorDongeun Yong-
dc.identifier.doi10.3390/cells9102209-
dc.contributor.localIdA02423-
dc.relation.journalcodeJ03774-
dc.identifier.pmid33003541-
dc.subject.keywordblood vessel-
dc.subject.keywordcolon-
dc.subject.keywordenteric nervous system-
dc.subject.keywordhuman embryonic stem cell-
dc.subject.keywordorganoid-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.affiliatedAuthor용동은-
dc.citation.volume9-
dc.citation.number10-
dc.citation.startPage2209-
dc.identifier.bibliographicCitationCELLS, Vol.9(10) : 2209, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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