25 42

Cited 0 times in

Prognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author한승혁-
dc.date.accessioned2020-12-01T17:48:53Z-
dc.date.available2020-12-01T17:48:53Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180465-
dc.description.abstractBackground: Although the soluble form of suppression of tumorigenicity 2 (sST2) and soluble low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11) have emerged as novel cardiovascular biomarkers in patients with cardiovascular disease, their prognostic value has not been fully investigated in peritoneal dialysis (PD) patients. Methods: We included 74 prevalent PD patients from a prospective cohort and measured serum sST2 and sLR11 concentrations by an enzyme-linked immunosorbent assay. The association of these biomarkers and all-cause mortality and major adverse cardiac and cerebrovascular events (MACCEs) was evaluated. Results: During a follow-up of 38.5 months, all-cause deaths and MACCEs were observed in 13 (17.6%) patients and 23 (31.3%) patients. Multivariable Cox analyses demonstrated that greater sST2 was independently associated with higher risk of all-cause mortality (≥75.8 ng/mL; hazard ratio [HR] = 5.551; 95% confidence interval [CI] = 1.360-22.660) and MACCEs (≥72.5 ng/mL; HR = 4.609; 95% CI = 1.608-13.208). Furthermore, sST2 showed additive predictive value for mortality to the base model including traditional risk factors (net reclassification index = 0.598, P = 0.04). sLR11 was not significantly associated with all-cause mortality or MACCE. Conclusions: sST2, but not sLR11, indicated a significant prognostic value for all-cause mortality and cardiovascular events in PD patients. Further research is needed to validate emerging biomarkers in these populations.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYu Bum Choi-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorHyung Jong Kim-
dc.identifier.doi10.1186/s12882-020-01886-7-
dc.contributor.localIdA00053-
dc.contributor.localIdA01654-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ00367-
dc.identifier.eissn1471-2369-
dc.identifier.pmid32539731-
dc.subject.keywordBiomarker-
dc.subject.keywordMajor adverse cardiac and cerebrovascular events-
dc.subject.keywordPeritoneal dialysis-
dc.subject.keywordSoluble LR11-
dc.subject.keywordSoluble ST2-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor한승혁-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage228-
dc.identifier.bibliographicCitationBMC NEPHROLOGY, Vol.21(1) : 228, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.