Cited 33 times in
Prognostic significance of and risk prediction model for lymph node metastasis in resectable intrahepatic cholangiocarcinoma: do all require lymph node dissection?
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.contributor.author | 노승윤 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 한대훈 | - |
dc.date.accessioned | 2020-12-01T17:46:33Z | - |
dc.date.available | 2020-12-01T17:46:33Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1365-182X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180444 | - |
dc.description.abstract | Background: Lymph node (LN) metastasis portends a worse prognosis following resection of intrahepatic cholangiocarcinoma (ICC); however, lymphadenectomy is not routinely performed, as its role remains controversial. Herein, we developed a risk model for LN metastasis by identifying its predictive factors and assessed a subset of patients who might not benefit from LN dissection (LND). Methods: 210 patients who underwent curative-intent surgery for ICC were retrospectively reviewed. A preoperative risk model for LN metastasis was developed following identification of its preoperative predictive factors using the recursive partitioning method. Results: In the multivariable analysis, CA 19-9 level of >120 U/mL, an enlarged LN on computed tomography, and a tumor location abutting the Glissonean pedicles were independent predictors of LN metastasis. The preoperative risk model classified the patients according to their risk: high, intermediate, and low risks at a rate of LN metastasis on final pathology of 60.9%, 35%, and 2.3%, respectively. In the subgroup analysis among the low-risk patients, performance of LND had no survival advantage over non-performance of LND. Conclusion: Routine LND for preoperatively diagnosed ICC should be recommended to patients at an intermediate and a high risk of developing LN metastasis but may be omitted for low-risk patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | HPB | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prognostic significance of and risk prediction model for lymph node metastasis in resectable intrahepatic cholangiocarcinoma: do all require lymph node dissection? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jonathan G Navarro | - |
dc.contributor.googleauthor | Jin Ho Lee | - |
dc.contributor.googleauthor | Incheon Kang | - |
dc.contributor.googleauthor | Seoung Yoon Rho | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Dai Hoon Han | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.identifier.doi | 10.1016/j.hpb.2020.01.009 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A05469 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A04273 | - |
dc.relation.journalcode | J03345 | - |
dc.identifier.eissn | 1477-2574 | - |
dc.identifier.pmid | 32046923 | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1365182X20300253 | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | 김경식 | - |
dc.contributor.affiliatedAuthor | 노승윤 | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.contributor.affiliatedAuthor | 최진섭 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1411 | - |
dc.citation.endPage | 1419 | - |
dc.identifier.bibliographicCitation | HPB, Vol.22(10) : 1411-1419, 2020-10 | - |
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