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Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis

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dc.contributor.author신재일-
dc.date.accessioned2020-12-01T17:46:07Z-
dc.date.available2020-12-01T17:46:07Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180438-
dc.description.abstractBackground: Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The objective of this network meta-analysis (NMA) is to determine the relative efficacy and acceptability of primary care treatments for non-specific CLBP, with the overarching aim of providing a comprehensive evidence base for informing treatment decisions. Methods: We will perform a systematic search to identify randomised controlled trials of interventions endorsed in primary care guidelines for the treatment of non-specific CLBP in adults. Information sources searched will include major bibliographic databases (MEDLINE, Embase, CENTRAL, CINAHL, PsycINFO and LILACS) and clinical trial registries. Our primary outcomes will be patient-reported pain ratings and treatment acceptability (all-cause discontinuation), and secondary outcomes will be functional ability, quality of life and patient/physician ratings of overall improvement. A hierarchical Bayesian class-based NMA will be performed to determine the relative effects of different classes of pharmacological (NSAIDs, opioids, paracetamol, anti-depressants, muscle relaxants) and non-pharmacological (exercise, patient education, manual therapies, psychological therapy, multidisciplinary approaches, massage, acupuncture, mindfulness) interventions and individual treatments within a class (e.g. NSAIDs: diclofenac, ibuprofen, naproxen). We will conduct risk of bias assessments and threshold analysis to assess the robustness of the findings to potential bias. We will compute the effect of different interventions relative to placebo/no treatment for both short- and long-term efficacy and acceptability. Discussion: While many factors are important in selecting an appropriate intervention for an individual patient, evidence for the analgesic effects and acceptability of a treatment are key factors in guiding this selection. Thus, this NMA will provide an important source of evidence to inform treatment decisions and future clinical guidelines. Systematic review registration: PROSPERO registry number: CRD42019138115.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfSYSTEMATIC REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEfficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorTrevor Thompson-
dc.contributor.googleauthorSofia Dias-
dc.contributor.googleauthorDamian Poulter-
dc.contributor.googleauthorSharon Weldon-
dc.contributor.googleauthorLucy Marsh-
dc.contributor.googleauthorClaire Rossato-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorJoseph Firth-
dc.contributor.googleauthorNicola Veronese-
dc.contributor.googleauthorElena Dragioti-
dc.contributor.googleauthorBrendon Stubbs-
dc.contributor.googleauthorMarco Solmi-
dc.contributor.googleauthorChristopher G Maher-
dc.contributor.googleauthorAndrea Cipriani-
dc.contributor.googleauthorJohn P A Ioannidis-
dc.identifier.doi10.1186/s13643-020-01398-3-
dc.contributor.localIdA02142-
dc.relation.journalcodeJ03950-
dc.identifier.eissn2046-4053-
dc.identifier.pmid32503666-
dc.subject.keywordLow back pain-
dc.subject.keywordNetwork meta-analysis-
dc.subject.keywordProtocol-
dc.subject.keywordRandomized controlled trial-
dc.subject.keywordSystematic review-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage130-
dc.identifier.bibliographicCitationSYSTEMATIC REVIEWS, Vol.9(1) : 130, 2020-06-
dc.identifier.rimsid67240-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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