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Cited 26 times in

Dopaminergic Depletion, β-Amyloid Burden, and Cognition in Lewy Body Disease

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author유한수-
dc.contributor.author윤미진-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2020-12-01T17:45:23Z-
dc.date.available2020-12-01T17:45:23Z-
dc.date.issued2020-05-
dc.identifier.issn0364-5134-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180432-
dc.description.abstractObjective: We aimed to determine the association between striatal dopaminergic depletion, cerebral β-amyloid deposition, and cognitive dysfunction in Lewy body disease (LBD). Methods: This cross-sectional study recruited 48 LBD patients (30 with dementia, 18 with mild cognitive impairment) and 15 control subjects from a university-based hospital. We measured the striatal dopamine transporter (DAT) activity and regional β-amyloid burden using N-(3-[18 F]fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography (PET) and 18 F-florbetaben (FBB) PET, respectively. The relationship between striatal FP-CIT uptake, regional cortical FBB uptake, and cognitive function scores was evaluated using path analyses. We also investigated the effects of striatal FP-CIT uptake and cortical FBB uptake on the interval between motor symptom and dementia onset. Results: Reduced striatal FP-CIT uptake was associated with increased FBB uptake in the posterior cortical regions, most prominently in the occipital cortices. Reduced FP-CIT uptake in the anterior putamen was associated with visuospatial dysfunction with mediation of increased occipital FBB uptake. Reduced FP-CIT uptake in the posterior putamen and an increased parietal FBB uptake were independently associated with memory dysfunction. Reduced striatal FP-CIT uptake was associated with attention, language, and frontal/executive dysfunction, independent of amyloid deposition. Increased FBB uptake, especially in the parietal cortex, was associated with earlier onset of dementia. Interpretation: Our results suggest that occipital β-amyloid deposition may contribute to the association between striatal dopaminergic depletion and visuospatial dysfunction in LBD patients. Although the effects of reduced DAT activity are more prominent than those of β-amyloid burden on cognitive dysfunction, the latter affects the onset of cognitive dysfunction.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfANNALS OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAmyloid beta-Peptides / metabolism*-
dc.subject.MESHBrain / diagnostic imaging-
dc.subject.MESHBrain / metabolism-
dc.subject.MESHBrain / pathology-
dc.subject.MESHCognition / physiology-
dc.subject.MESHCognitive Dysfunction / etiology*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins / metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLewy Body Disease / complications-
dc.subject.MESHLewy Body Disease / metabolism*-
dc.subject.MESHLewy Body Disease / pathology*-
dc.subject.MESHMale-
dc.subject.MESHPositron-Emission Tomography-
dc.titleDopaminergic Depletion, β-Amyloid Burden, and Cognition in Lewy Body Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorSangwon Lee-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorSeungyeoun Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorByoung Seok Ye-
dc.identifier.doi10.1002/ana.25707-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA05367-
dc.contributor.localIdA02550-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ00166-
dc.identifier.eissn1531-8249-
dc.identifier.pmid32078179-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/ana.25707-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume87-
dc.citation.number5-
dc.citation.startPage739-
dc.citation.endPage750-
dc.identifier.bibliographicCitationANNALS OF NEUROLOGY, Vol.87(5) : 739-750, 2020-05-
dc.identifier.rimsid67408-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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