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Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke

DC FieldValueLanguage
dc.contributor.author윤미진-
dc.date.accessioned2020-12-01T17:45:16Z-
dc.date.available2020-12-01T17:45:16Z-
dc.date.issued2020-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180430-
dc.description.abstractGlucose hypometabolism in cortical structures after functional disconnection is frequently reported in patients with white matter diseases such as subcortical stroke. However, the molecular and cellular mechanisms have been poorly elucidated. Here we show, in an animal model of internal capsular infarct, that GABA-synthesizing reactive astrocytes in distant cortical areas cause glucose hypometabolism via tonic inhibition of neighboring neurons. We find that reversal of aberrant astrocytic GABA synthesis, by pharmacological inhibition and astrocyte-specific gene silencing of MAO-B, reverses the reduction in cortical glucose metabolism. Moreover, induction of aberrant astrocytic GABA synthesis by cortical injection of putrescine or adenovirus recapitulates cortical hypometabolism. Furthermore, MAO-B inhibition causes a remarkable recovery from post-stroke motor deficits when combined with a rehabilitation regimen. Collectively, our data indicate that cortical glucose hypometabolism in subcortical stroke is caused by aberrant astrocytic GABA and MAO-B inhibition and that attenuating cortical hypometabolism can be a therapeutic approach in subcortical stroke.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCELL REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleExcessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorMin-Ho Nam-
dc.contributor.googleauthorJongwook Cho-
dc.contributor.googleauthorDae-Hyuk Kwon-
dc.contributor.googleauthorJi-Young Park-
dc.contributor.googleauthorJunsung Woo-
dc.contributor.googleauthorJung Moo Lee-
dc.contributor.googleauthorSangwon Lee-
dc.contributor.googleauthorHae Young Ko-
dc.contributor.googleauthorWoojin Won-
dc.contributor.googleauthorRa Gyung Kim-
dc.contributor.googleauthorHanlim Song-
dc.contributor.googleauthorSoo-Jin Oh-
dc.contributor.googleauthorJi Won Choi-
dc.contributor.googleauthorKi Duk Park-
dc.contributor.googleauthorEun Kyung Park-
dc.contributor.googleauthorHaejin Jung-
dc.contributor.googleauthorHyung-Seok Kim-
dc.contributor.googleauthorMin-Cheol Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorC Justin Lee-
dc.contributor.googleauthorHyoung-Ihl Kim-
dc.identifier.doi10.1016/j.celrep.2020.107861-
dc.contributor.localIdA02550-
dc.relation.journalcodeJ00488-
dc.identifier.eissn2211-1247-
dc.identifier.pmid32640227-
dc.subject.keywordGABA-
dc.subject.keywordPET imaging-
dc.subject.keywordastrocyte-
dc.subject.keyworddiaschisis-
dc.subject.keywordinternal capsule-
dc.subject.keywordmonoamine oxidase B-
dc.subject.keywordreactive astrocyte-
dc.subject.keywordrehabilitation-
dc.subject.keywordstroke-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.affiliatedAuthor윤미진-
dc.citation.volume32-
dc.citation.number1-
dc.citation.startPage107861-
dc.identifier.bibliographicCitationCELL REPORTS, Vol.32(1) : 107861, 2020-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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