Cited 53 times in
Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke
DC Field | Value | Language |
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dc.contributor.author | 윤미진 | - |
dc.date.accessioned | 2020-12-01T17:45:16Z | - |
dc.date.available | 2020-12-01T17:45:16Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180430 | - |
dc.description.abstract | Glucose hypometabolism in cortical structures after functional disconnection is frequently reported in patients with white matter diseases such as subcortical stroke. However, the molecular and cellular mechanisms have been poorly elucidated. Here we show, in an animal model of internal capsular infarct, that GABA-synthesizing reactive astrocytes in distant cortical areas cause glucose hypometabolism via tonic inhibition of neighboring neurons. We find that reversal of aberrant astrocytic GABA synthesis, by pharmacological inhibition and astrocyte-specific gene silencing of MAO-B, reverses the reduction in cortical glucose metabolism. Moreover, induction of aberrant astrocytic GABA synthesis by cortical injection of putrescine or adenovirus recapitulates cortical hypometabolism. Furthermore, MAO-B inhibition causes a remarkable recovery from post-stroke motor deficits when combined with a rehabilitation regimen. Collectively, our data indicate that cortical glucose hypometabolism in subcortical stroke is caused by aberrant astrocytic GABA and MAO-B inhibition and that attenuating cortical hypometabolism can be a therapeutic approach in subcortical stroke. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Min-Ho Nam | - |
dc.contributor.googleauthor | Jongwook Cho | - |
dc.contributor.googleauthor | Dae-Hyuk Kwon | - |
dc.contributor.googleauthor | Ji-Young Park | - |
dc.contributor.googleauthor | Junsung Woo | - |
dc.contributor.googleauthor | Jung Moo Lee | - |
dc.contributor.googleauthor | Sangwon Lee | - |
dc.contributor.googleauthor | Hae Young Ko | - |
dc.contributor.googleauthor | Woojin Won | - |
dc.contributor.googleauthor | Ra Gyung Kim | - |
dc.contributor.googleauthor | Hanlim Song | - |
dc.contributor.googleauthor | Soo-Jin Oh | - |
dc.contributor.googleauthor | Ji Won Choi | - |
dc.contributor.googleauthor | Ki Duk Park | - |
dc.contributor.googleauthor | Eun Kyung Park | - |
dc.contributor.googleauthor | Haejin Jung | - |
dc.contributor.googleauthor | Hyung-Seok Kim | - |
dc.contributor.googleauthor | Min-Cheol Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | C Justin Lee | - |
dc.contributor.googleauthor | Hyoung-Ihl Kim | - |
dc.identifier.doi | 10.1016/j.celrep.2020.107861 | - |
dc.contributor.localId | A02550 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 32640227 | - |
dc.subject.keyword | GABA | - |
dc.subject.keyword | PET imaging | - |
dc.subject.keyword | astrocyte | - |
dc.subject.keyword | diaschisis | - |
dc.subject.keyword | internal capsule | - |
dc.subject.keyword | monoamine oxidase B | - |
dc.subject.keyword | reactive astrocyte | - |
dc.subject.keyword | rehabilitation | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 107861 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.32(1) : 107861, 2020-07 | - |
dc.identifier.rimsid | 67084 | - |
dc.type.rims | ART | - |
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