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COVID-19 and Adverse Pregnancy Outcome: A Systematic Review of 104 Cases

DC FieldValueLanguage
dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2020-12-01T17:44:53Z-
dc.date.available2020-12-01T17:44:53Z-
dc.date.issued2020-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180427-
dc.description.abstract(1) Background: Until now, several reports about pregnant women with confirmed coronavirus disease 2019 (COVID-19) have been published. However, there are no comprehensive systematic reviews collecting all case series studies on data regarding adverse pregnancy outcomes, especially association with treatment modalities. (2) Objective: We aimed to synthesize the most up-to-date and relevant available evidence on the outcomes of pregnant women with laboratory-confirmed infection with COVID-19. (3) Methods: PubMed, Scopus, MEDLINE, Google scholar, and Embase were explored for studies and papers regarding pregnant women with COVID-19, including obstetrical, perinatal, and neonatal outcomes and complications published from 1 January 2020 to 4 May 2020. Systematic review and search of the published literature was done using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). (4) Results: In total, 11 case series studies comprising 104 pregnant women with COVID-19 were included in our review. Fever (58.6%) and cough (30.7%) were the most common symptoms. Other symptoms included dyspnea (14.4%), chest discomfort (3.9%), sputum production (1.0%), sore throat (2.9%), and nasal obstruction (1.0%). Fifty-two patients (50.0%) eventually demonstrated abnormal chest CT, and of those with ground glass opacity (GGO), 23 (22.1%) were bilateral and 10 (9.6%) were unilateral. The most common treatment for COVID-19 was administration of antibiotics (25.9%) followed by antivirals (17.3%). Cesarean section was the mode of delivery for half of the women (50.0%), although no information was available for 28.8% of the cases. Regarding obstetrical and neonatal outcomes, fetal distress (13.5%), pre-labor rupture of membranes (9.6%), prematurity (8.7%), fetal death (4.8%), and abortion (2.9%) were reported. There are no positive results of neonatal infection by RT-PCR. (5) Conclusions: Although we have found that pregnancy with COVID-19 has significantly higher maternal mortality ratio compared to that of pregnancy without the disease, the evidence is too weak to state that COVID-19 results in poorer maternal outcome due to multiple factors. The number of COVID-19 pregnancy outcomes was not large enough to draw a conclusion and long-term outcomes are yet to be determined as the pandemic is still unfolding. Active and intensive follow-up is needed in order to provide robust data for future studies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCOVID-19 and Adverse Pregnancy Outcome: A Systematic Review of 104 Cases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorRamy Abou Ghayda-
dc.contributor.googleauthorHan Li-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorHee Won Lee-
dc.contributor.googleauthorSung Hwi Hong-
dc.contributor.googleauthorMoonsu Kwak-
dc.contributor.googleauthorMinwoo Lee-
dc.contributor.googleauthorMinjae Kwon-
dc.contributor.googleauthorAi Koyanagi-
dc.contributor.googleauthorAndreas Kronbichler-
dc.contributor.googleauthorLouis Jacob-
dc.contributor.googleauthorLee Smith-
dc.contributor.googleauthorJae Il Shin-
dc.identifier.doi10.3390/jcm9113441-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid33114779-
dc.subject.keywordCOVID-19-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordcoronavirus disease 2019-
dc.subject.keywordfetal death-
dc.subject.keywordmaternal morbidity-
dc.subject.keywordmaternal mortality-
dc.subject.keywordneonatal morbidity-
dc.subject.keywordneonatal mortality-
dc.subject.keywordneonatal outcomes-
dc.subject.keywordpregnancy-
dc.subject.keywordpreterm birth-
dc.subject.keywordstillbirth-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이금화-
dc.contributor.affiliatedAuthor이금화-
dc.citation.volume9-
dc.citation.number11-
dc.citation.startPage3441-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.9(11) : 3441, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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