Cited 43 times in
KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2020-12-01T17:44:50Z | - |
dc.date.available | 2020-12-01T17:44:50Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0392-9078 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180426 | - |
dc.description.abstract | Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases.The genetic landscape of KRAS wild type PDAC can be divided into three categories. The first is represented by tumors with an activated MAPK pathway due to BRAF mutation that occur in up to 4% of cases. The second includes tumors with microsatellite instability (MSI) due to defective DNA mismatch repair (dMMR), which occurs in about 2% of cases, also featuring a high tumor mutational burden. The third category is represented by tumors with kinase fusion genes, which marks about 4% of cases. While therapeutic molecular targeting of KRAS is an unresolved challenge, KRAS-wild type PDACs have potential options for tailored treatments, including BRAF antagonists and MAPK inhibitors for the first group, immunotherapy with anti-PD-1/PD-L1 agents for the MSI/dMMR group, and kinase inhibitors for the third group.This calls for a complementation of the histological diagnosis of PDAC with a routine determination of KRAS followed by a comprehensive molecular profiling of KRAS-negative cases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Claudio Luchini | - |
dc.contributor.googleauthor | Gaetano Paolino | - |
dc.contributor.googleauthor | Paola Mattiolo | - |
dc.contributor.googleauthor | Maria L Piredda | - |
dc.contributor.googleauthor | Alessandro Cavaliere | - |
dc.contributor.googleauthor | Marina Gaule | - |
dc.contributor.googleauthor | Davide Melisi | - |
dc.contributor.googleauthor | Roberto Salvia | - |
dc.contributor.googleauthor | Giuseppe Malleo | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Sarah Cargnin | - |
dc.contributor.googleauthor | Salvatore Terrazzino | - |
dc.contributor.googleauthor | Rita T Lawlor | - |
dc.contributor.googleauthor | Michele Milella | - |
dc.contributor.googleauthor | Aldo Scarpa | - |
dc.identifier.doi | 10.1186/s13046-020-01732-6 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J03807 | - |
dc.identifier.eissn | 1756-9966 | - |
dc.identifier.pmid | 33115526 | - |
dc.subject.keyword | BRAF | - |
dc.subject.keyword | KRAS | - |
dc.subject.keyword | MSI | - |
dc.subject.keyword | dMMR | - |
dc.subject.keyword | fusion genes | - |
dc.subject.keyword | pancreatic cancer | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 227 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, Vol.39(1) : 227, 2020-10 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.