Cited 14 times in
Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.date.accessioned | 2020-12-01T17:44:10Z | - |
dc.date.available | 2020-12-01T17:44:10Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180416 | - |
dc.description.abstract | Eosinophilic esophagitis (EoE) is a relatively new condition described as an allergic-mediated disease of the esophagus. Clinically, it is characterized by dysphagia, food impaction, and reflux-like symptoms. Multiple genome-wide association studies (GWAS) have been conducted to identify genetic loci associated with EoE. The integration of numerous studies investigating the genetic polymorphisms in EoE and the Mendelian diseases associated with EoE are discussed to provide insights into the genetic risk of EoE, notably focusing on CCL26 and CAPN14. We focus on the genetic loci investigated thus far, and their classification according to whether the function near the loci is known. The pathophysiology of EoE is described by separately presenting the known function of each cell and molecule, with the major contributors being eosinophils, Th2 cells, thymic stromal lymphopoietin (TSLP), transforming growth factor (TGF)-β1, and interleukin (IL)-13. This review aims to provide detailed descriptions of the genetics and the comprehensive pathophysiology of EoE. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Seohyun Ryu | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Kalthoum Tizaoui | - |
dc.contributor.googleauthor | Salvatore Terrazzino | - |
dc.contributor.googleauthor | Sarah Cargnin | - |
dc.contributor.googleauthor | Maria Effenberger | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.identifier.doi | 10.3390/ijms21197253 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33008138 | - |
dc.subject.keyword | genetic susceptibility | - |
dc.subject.keyword | pathophysiology | - |
dc.subject.keyword | polymorphism | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.contributor.affiliatedAuthor | 이금화 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 7253 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(19) : 7253, 2020-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.