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Genetic variation and autism: A field synopsis and systematic meta-analysis

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dc.contributor.author신재일-
dc.contributor.author이금화-
dc.contributor.author이광섭-
dc.date.accessioned2020-12-01T17:43:59Z-
dc.date.available2020-12-01T17:43:59Z-
dc.date.issued2020-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180414-
dc.description.abstractThis study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfBRAIN SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGenetic variation and autism: A field synopsis and systematic meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJinhee Lee-
dc.contributor.googleauthorMin Ji Son-
dc.contributor.googleauthorChei Yun Son-
dc.contributor.googleauthorGwang Hun Jeong-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorKwang Seob Lee-
dc.contributor.googleauthorYounhee Ko-
dc.contributor.googleauthorJong Yeob Kim-
dc.contributor.googleauthorJun Young Lee-
dc.contributor.googleauthorJoaquim Radua-
dc.contributor.googleauthorMichael Eisenhut-
dc.contributor.googleauthorFlorence Gressier-
dc.contributor.googleauthorAi Koyanagi-
dc.contributor.googleauthorBrendon Stubbs-
dc.contributor.googleauthorMarco Solmi-
dc.contributor.googleauthorTheodor B Rais-
dc.contributor.googleauthorAndreas Kronbichler-
dc.contributor.googleauthorElena Dragioti-
dc.contributor.googleauthorDaniel Fernando Pereira Vasconcelos-
dc.contributor.googleauthorFelipe Rodolfo Pereira da Silva-
dc.contributor.googleauthorKalthoum Tizaoui-
dc.contributor.googleauthorAndré Russowsky Brunoni-
dc.contributor.googleauthorAndre F Carvalho-
dc.contributor.googleauthorSarah Cargnin-
dc.contributor.googleauthorSalvatore Terrazzino-
dc.contributor.googleauthorAndrew Stickley-
dc.contributor.googleauthorLee Smith-
dc.contributor.googleauthorTrevor Thompson-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorPaolo Fusar-Poli-
dc.identifier.doi10.3390/brainsci10100692-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03916-
dc.identifier.eissn2076-3425-
dc.identifier.pmid33007889-
dc.subject.keywordBayesian false-discovery probability (BFDP)-
dc.subject.keywordGenome-Wide Association Studies (GWAS)-
dc.subject.keywordautism spectrum disorder-
dc.subject.keywordfalse positive report probability (FPRP)-
dc.subject.keywordmeta-analysis-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이금화-
dc.citation.volume10-
dc.citation.number10-
dc.citation.startPage692-
dc.identifier.bibliographicCitationBRAIN SCIENCES, Vol.10(10) : 692, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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