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Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes

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dc.contributor.author전경희-
dc.date.accessioned2020-12-01T17:43:18Z-
dc.date.available2020-12-01T17:43:18Z-
dc.date.issued2020-09-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180404-
dc.description.abstractRecently, tumor microenvironment (TME) and its stromal constituents have provided profound insights into understanding alterations in tumor behavior. After each identification regarding the unique roles of TME compartments, non-malignant stromal cells are found to provide a sufficient tumorigenic niche for cancer cells. Of these TME constituents, adipocytes represent a dynamic population mediating endocrine effects to facilitate the crosstalk between cancer cells and distant organs, as well as the interplay with nearby tumor cells. To date, the prevalence of obesity has emphasized the significance of metabolic homeostasis along with adipose tissue (AT) inflammation, cancer incidence, and multiple pathological disorders. In this review, we summarized distinct characteristics of hypertrophic adipocytes and cancer to highlight the importance of an individual's metabolic health during cancer therapy. As AT undergoes inflammatory alterations inducing tissue remodeling, immune cell infiltration, and vascularization, these features directly influence the TME by favoring tumor progression. A comparison between inflammatory AT and progressing cancer could potentially provide crucial insights into delineating the complex communication network between uncontrolled hyperplastic tumors and their microenvironmental components. In turn, the comparison will unravel the underlying properties of dynamic tumor behavior, advocating possible therapeutic targets within TME constituents.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.relation.isPartOfMOLECULES AND CELLS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClassifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorYae Chan Song-
dc.contributor.googleauthorSeung Eon Lee-
dc.contributor.googleauthorYoung Jin-
dc.contributor.googleauthorHyun Woo Park-
dc.contributor.googleauthorKyung-Hee Chun-
dc.contributor.googleauthorHan-Woong Lee-
dc.identifier.doi10.14348/molcells.2020.0118-
dc.contributor.localIdA03501-
dc.relation.journalcodeJ02273-
dc.identifier.eissn0219-1032-
dc.identifier.pmid32759466-
dc.subject.keywordadipose tissue-
dc.subject.keywordcancer-associated adipocyte-
dc.subject.keywordinflammation-
dc.subject.keywordobesity-
dc.subject.keywordtumor microenvironment-
dc.contributor.alternativeNameChun, Kyung Hee-
dc.contributor.affiliatedAuthor전경희-
dc.citation.volume43-
dc.citation.number9-
dc.citation.startPage763-
dc.citation.endPage773-
dc.identifier.bibliographicCitationMOLECULES AND CELLS, Vol.43(9) : 763-773, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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