137 401

Cited 12 times in

Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner

DC Field Value Language
dc.contributor.author전경희-
dc.date.accessioned2020-12-01T17:43:00Z-
dc.date.available2020-12-01T17:43:00Z-
dc.date.issued2020-08-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180400-
dc.description.abstractBee venom (BV), secreted from the venom gland of the honey bee, contains several biological active compounds. BV has been widely used as a traditional medicine for treating human disease, including cancer. In this study, we have shown the molecular mechanism underlying the therapeutic effect of BV on cancer. Treatment with BV reduced the proliferation of cervical-cancer cells in a dose- and time-dependent manner. Interestingly, the killing effect of BV was specific to HPVpositive cervical-cancer cell lines, such as Caski and HeLa cells, and not to HPV-negative cervical-cancer cells (C33A). BV reduced the expression of HPV E6 and E7 at RNA and protein levels, leading to an increase in the expression of p53 and Rb in Caski and HeLa cells. Further, BV decreased the levels of cell-cycle proteins, such as cyclin A and B, and increased the levels of cell-cycle inhibitors, such as p21 and p27. BV significantly induced apoptosis and inhibited wound healing and migration of cervical-cancer cells. It also upregulated the expression of pro-apoptotic BAX and downregulated the expression of anti-apoptotic Bcl-2 and Bcl-XL. Cleavage of caspase-3, caspase-9, and PARP were also induced by BV treatment, whereas the phosphorylation of mitogenic signalingrelated proteins, such as AKT, JNK, p38, and ERK, were downregulated. Our results indicate that BV has a therapeutic selectivity for HPV-positive malignant cells, so further clinical studies are needed to assess its clinical application.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorDa-Hyun Kim-
dc.contributor.googleauthorHyun-Woo Lee-
dc.contributor.googleauthorHyun-Woo Park-
dc.contributor.googleauthorHan-Woong Lee-
dc.contributor.googleauthorKyung-Hee Chun-
dc.identifier.doi10.5483/BMBRep.2020.53.8.031-
dc.contributor.localIdA03501-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid32317085-
dc.contributor.alternativeNameChun, Kyung Hee-
dc.contributor.affiliatedAuthor전경희-
dc.citation.volume53-
dc.citation.number8-
dc.citation.startPage419-
dc.citation.endPage424-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.53(8) : 419-424, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.