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Factors associated with improvement in MELD score after antiviral treatment in patients with chronic hepatitis B

DC Field Value Language
dc.contributor.author안상훈-
dc.contributor.author이혜원-
dc.date.accessioned2020-12-01T17:42:55Z-
dc.date.available2020-12-01T17:42:55Z-
dc.date.issued2020-09-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180399-
dc.description.abstractBackground and aims: Improvement in Model for End-Stage Liver Disease (MELD) score during antiviral treatment is associated with reduced hepatic decompensation and death in patients with chronic hepatitis B (CHB)-related cirrhosis. We aimed to identify factors associated with transplant-free survival and on-treatment MELD score improvement. Methods: We identified patients with CHB-related cirrhosis and MELD score ≥ 15 at the start of entecavir and/or tenofovir disoproxil fumarate treatment between 2005 and 2017. The primary endpoint was transplant-free survival at month 6. The secondary endpoints at month 6 were transplant-free survival with > 5-point improvement in MELD score and transplant-free survival with MELD score < 15. Results: Of 999 cirrhotic CHB patients, 605 (60.6%) achieved transplant-free survival at month 6. Proportion of transplant-free survival at month 6 stabilized at 10% in patients with high MELD. Patients who achieved transplant-free survival at month 6 were younger, had lower MELD score, lower alanine aminotransferase (ALT), and higher albumin at baseline. Of 605 patients with transplant-free survival, 276 (45.6%) achieved > 5-point improvement in MELD score; 183 (30.2%) had 1-point to 5-point improvement in MELD score; 146 (24.1%) had no improvement or a worsened MELD score. Also, 321 (53.1%) patients with transplant-free survival had a MELD score < 15 at month 6. Conclusion: On top of lower MELD score, patients with CHB-related cirrhosis who are younger, have higher albumin, and lower ALT are more likely to achieve transplant-free survival after 6 months of antiviral treatment.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAlanine Transaminase / blood-
dc.subject.MESHAntiviral Agents / therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHGuanine / analogs & derivatives*-
dc.subject.MESHGuanine / therapeutic use-
dc.subject.MESHHepatitis B, Chronic / complications-
dc.subject.MESHHepatitis B, Chronic / drug therapy*-
dc.subject.MESHHepatitis B, Chronic / mortality*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis / drug therapy-
dc.subject.MESHLiver Cirrhosis / etiology-
dc.subject.MESHLiver Cirrhosis / mortality-
dc.subject.MESHLiver Failure / etiology-
dc.subject.MESHLiver Failure / prevention & control-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHResearch Design*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerum Albumin-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTenofovir / therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.titleFactors associated with improvement in MELD score after antiviral treatment in patients with chronic hepatitis B-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTerry Cheuk-Fung Yip-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorVincent Wai-Sun Wong-
dc.contributor.googleauthorGrace Lai-Hung Wong-
dc.contributor.googleauthorYee-Kit Tse-
dc.contributor.googleauthorGrace Chung-Yan Lui-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorHenry Lik-Yuen Chan-
dc.identifier.doi10.1111/jgh.15007-
dc.contributor.localIdA02226-
dc.contributor.localIdA03318-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid32032974-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jgh.15007-
dc.subject.keywordMELD improvement-
dc.subject.keywordliver cirrhosis-
dc.subject.keywordtransplant-free survival-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이혜원-
dc.citation.volume35-
dc.citation.number9-
dc.citation.startPage1610-
dc.citation.endPage1618-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.35(9) : 1610-1618, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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