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Potential causal association of a prolonged PR interval and clinical recurrence of atrial fibrillation after catheter ablation: a Mendelian randomization analysis

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dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author유희태-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.contributor.author지선하-
dc.date.accessioned2020-12-01T17:41:53Z-
dc.date.available2020-12-01T17:41:53Z-
dc.date.issued2020-10-
dc.identifier.issn1434-5161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180392-
dc.description.abstractA prolonged PR interval predicts atrial fibrillation (AF) recurrence after catheter ablation. We investigated the causal association between the PR interval and AF clinical recurrence by a Mendelian randomization. We prospectively included 1722 patients with AF (73.2% male, 58.6 ± 10.8 years old, 71.3% paroxysmal AF) who underwent catheter ablation into a genome-wide association study (GWAS). We searched for the genetic associations between the PR interval and AF recurrence by analyzing 44 single nucleotide polymorphisms (SNPs) already known to be associated with the PR interval, and investigated the Mendelian randomization. Based on the quartile analysis, the highest quartile of the PR interval was associated with an increased risk of AF recurrence compared with the lowest quartile (Hazard ratio (HR) = 1.91, 95% CI = 1.51-2.42, P = 8.41 × 10-8) during 35.7 ± 28.5 months of follow-up. Among 44 SNPs known to be associated with the PR interval, two SNPs had significant associations with the PR interval (P < 0.001 for each SNP). CAV1 (HR = 1.15, 95% CI = 1.02-1.31, P = 0.024) was associated with clinical recurrence of AF. A Mendelian randomization analysis demonstrated a significant association with CAV1 (HR = 1.04, 95% CI = 1.01-1.07, P = 0.006). A prolonged PR interval was a risk factor for an AF recurrence, and the PR interval had a potentially causal association with an AF clinical recurrence after catheter ablation at the genetic level.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfJOURNAL OF HUMAN GENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePotential causal association of a prolonged PR interval and clinical recurrence of atrial fibrillation after catheter ablation: a Mendelian randomization analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMyunghee Hong-
dc.contributor.googleauthorInseok Hwang-
dc.contributor.googleauthorHee-Tae Yu-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1038/s10038-020-0774-2-
dc.contributor.localIdA01085-
dc.contributor.localIdA01776-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02337-
dc.contributor.localIdA02535-
dc.contributor.localIdA02535-
dc.contributor.localIdA02766-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA03609-
dc.contributor.localIdA03965-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ01446-
dc.identifier.eissn1435-232X-
dc.identifier.pmid32409696-
dc.identifier.urlhttps://www.nature.com/articles/s10038-020-0774-2-
dc.contributor.alternativeNameKim, Tae-Hoon-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor지선하-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume65-
dc.citation.number10-
dc.citation.startPage813-
dc.citation.endPage821-
dc.identifier.bibliographicCitationJOURNAL OF HUMAN GENETICS, Vol.65(10) : 813-821, 2020-10-
dc.identifier.rimsid67356-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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