Cited 7 times in
Risk Factors for Cytomegalovirus Reactivation in Lung Transplant Recipients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 백효채 | - |
dc.contributor.author | 이수환 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정수진 | - |
dc.date.accessioned | 2020-12-01T17:39:40Z | - |
dc.date.available | 2020-12-01T17:39:40Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0341-2040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180372 | - |
dc.description.abstract | Purpose: We examined risk factors that may have contributed to Cytomegalovirus (CMV) reactivation among patients who underwent lung transplantation (LTx). Methods: We reviewed medical records of patients who underwent LTx at a tertiary healthcare hospital in South Korea between January 2013 and May 2017. We excluded patients who died within the first year after LTx and those lost to follow-up. CMV reactivation was defined as the detection of CMV titers above 3000 copies/ml regardless of specific symptoms after prophylaxis cessation. Results: Of 89 patients included, 39 (43.8%) developed CMV reactivation. Of those 39 patients, 16 (41.0%) experienced additional CMV reactivation. Multivariate analysis identified lymphocyte counts below 1.0 × 103/μl (hazard ratio [HR] 49.33, p < 0.001) and use of steroids at more than twice the standard dose (HR 8.07, p < 0.001) as risk factors for CMV reactivation. The multivariate model also identified chronic kidney disease (CKD; HR 5.19, p = 0.016) and pneumonia (HR 17.22, p = 0.013) as risk factors for repetitive CMV reactivation. Conclusion: This study suggests that lymphopenia and high doses of steroids may be important risk factors for CMV reactivation in LTx patients. Our results also suggest that repetitive CMV reactivation may be associated with CKD and pneumonia. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | LUNG | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Risk Factors for Cytomegalovirus Reactivation in Lung Transplant Recipients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Se Hyun Kwak | - |
dc.contributor.googleauthor | Su Hwan Lee | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Hyo Chae Paik | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.identifier.doi | 10.1007/s00408-020-00380-z | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01846 | - |
dc.contributor.localId | A02904 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03638 | - |
dc.relation.journalcode | J02173 | - |
dc.identifier.eissn | 1432-1750 | - |
dc.identifier.pmid | 32696252 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00408-020-00380-z | - |
dc.subject.keyword | Cytomegalovirus | - |
dc.subject.keyword | Pulmonary disease | - |
dc.subject.keyword | Reactivation | - |
dc.subject.keyword | Risk factors | - |
dc.subject.keyword | Transplantation | - |
dc.contributor.alternativeName | Kim, Song Yee | - |
dc.contributor.affiliatedAuthor | 김송이 | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 백효채 | - |
dc.contributor.affiliatedAuthor | 이수환 | - |
dc.contributor.affiliatedAuthor | 이진구 | - |
dc.contributor.affiliatedAuthor | 장준 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.citation.volume | 198 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 829 | - |
dc.citation.endPage | 838 | - |
dc.identifier.bibliographicCitation | LUNG, Vol.198(5) : 829-838, 2020-10 | - |
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