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The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses

Authors
 Hye Jung Park  ;  Jung-Won Park  ;  Sae Hoon Kim  ;  So-Yun Choi  ;  Hee-Kyoo Kim  ;  Chang-Gyu Jung  ;  Min-Suk Yang  ;  Dong Yoon Kang  ;  Min-Kyoung Cho  ;  Hyouk-Soo Kwon  ;  Hye-Ryun Kang  ;  Yong Won Lee  ;  Allergy Work Group of KAAACI 
Citation
 EXPERT OPINION ON DRUG SAFETY, Vol.19(10) : 1349-1356, 2020-10 
Journal Title
 EXPERT OPINION ON DRUG SAFETY 
ISSN
 1474-0338 
Issue Date
2020-10
Keywords
Dapsone ; HLA-B*13:01 ; human leukocyte antigen ; hypersensitivity syndrome
Abstract
Background: The human leukocyte antigen (HLA)-B*13:01 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations. Research design and methods: From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies. Results: Among the seven DHS subjects, 85.7% presented with the HLA-B*13:01 allele. The HLA-C*03:04, HLA-DRB1*12:02 (both in linkage disequilibrium with HLA-B*13:01), and HLA-A*02:01 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*13:01 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) and the Korean general population (OR: 139.500). HLA-C*03:04 (OR: 40.935), HLA-DRB*12:02 (OR: 36.613), and HLA-A*02:01 (OR: 5.862) showed similar results. In meta-analysis, HLA-B*13:01 was associated with dapsone-induced hypersensitivity (overall OR: 42.692), and subgroup analyses according to the control types demonstrated similar results (OR:43.694 and 41.866, respectively). Conclusions: Similar to previous Asian population studies, HLA-B*13:01 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.
Full Text
https://www.tandfonline.com/doi/full/10.1080/14740338.2020.1796965
DOI
10.1080/14740338.2020.1796965
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Park, Hye Jung(박혜정) ORCID logo https://orcid.org/0000-0002-1862-1003
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180359
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