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Pregnancy Morbidities in Korean Patients with Takayasu Arteritis: A Monocentric Pilot Study

 Jung Yoon Pyo  ;  Jason Jungsik Song  ;  Yong Beom Park  ;  Sang Won Lee 
 YONSEI MEDICAL JOURNAL, Vol.61(11) : 970-975, 2020-11 
Journal Title
Issue Date
Adult ; Birth Rate ; Cesarean Section / statistics & numerical data ; Child ; Female ; Glucocorticoids / therapeutic use* ; Humans ; Hypertension / complications ; Hypertension / epidemiology ; Infant, Newborn ; Morbidity ; Pilot Projects ; Pre-Eclampsia / epidemiology ; Pregnancy ; Pregnancy Complications, Cardiovascular / diagnosis ; Pregnancy Complications, Cardiovascular / drug therapy* ; Pregnancy Complications, Cardiovascular / epidemiology ; Pregnancy Outcome / epidemiology* ; Republic of Korea / epidemiology ; Retrospective Studies ; Severity of Illness Index ; Takayasu Arteritis / diagnosis ; Takayasu Arteritis / drug therapy* ; Takayasu Arteritis / epidemiology
Arteritis ; morbidity ; pregnancy ; vasculitis
We investigated pregnancy morbidities in Korean patients with Takayasu arteritis (TA) in a single tertiary hospital as a pilot study. We retrospectively reviewed the medical records of 12 pregnancies in seven patients with TA. All patients were diagnosed with TA based on the 1990 American College of Rheumatology classification criteria. The medical records of patients were well-documented, allowing review of clinical data including pregnancy morbidities. The angiographic and Ishikawa classifications at diagnosis and TA activity at delivery were assessed. Of the 12 pregnancies, two pregnancies ended in spontaneous abortion (16.7%), and one pregnancy (8.3%) had therapeutic abortion at 9 weeks due to maternal morbidity. Among the remaining nine pregnancies, only one child was delivered via normal spontaneous vaginal delivery, and the remaining eight were delivered by Caesarean section. Two out of nine (22.2%) neonates were born with low birth weight, and one of them was born at 30 weeks of gestation. The most common maternal complication was hypertension affecting 7/12 (58.3%) pregnancies. Preeclampsia occurred in one pregnancy, and gestational diabetes mellitus (GDM) occurred in two pregnancies. At delivery, disease activity of TA was stable in all pregnancies, and glucocorticoids were administered in nine pregnancies. Live birth rate of pregnant Korean patients with TA was 75%. Future studies are needed to reduce pregnancy-related complications.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Lee, Sang-Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Pyo, Jung Yoon(표정윤)
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