0 38

Cited 0 times in

Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study

DC FieldValueLanguage
dc.contributor.author김진석-
dc.date.accessioned2020-12-01T17:31:58Z-
dc.date.available2020-12-01T17:31:58Z-
dc.date.issued2020-07-
dc.identifier.issn0925-5710-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180317-
dc.description.abstractAutologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (≥ very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3-4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Japan-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHFebrile Neutropenia / epidemiology-
dc.subject.MESHFebrile Neutropenia / etiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultiple Myeloma / therapy*-
dc.subject.MESHNausea / epidemiology-
dc.subject.MESHNausea / etiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStem Cell Transplantation* / adverse effects-
dc.subject.MESHStomatitis / epidemiology-
dc.subject.MESHTransplantation, Autologous-
dc.subject.MESHTreatment Outcome-
dc.titleAutologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJongheon Jung-
dc.contributor.googleauthorYoon Seok Choi-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorWon Sik Lee-
dc.contributor.googleauthorSung-Hyun Kim-
dc.contributor.googleauthorYong Park-
dc.contributor.googleauthorSeung-Shin Lee-
dc.contributor.googleauthorYoung Rok Do-
dc.contributor.googleauthorJae-Cheol Jo-
dc.contributor.googleauthorJe-Jung Lee-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorHo-Jin Shin-
dc.contributor.googleauthorDong-Yeop Shin-
dc.contributor.googleauthorSung-Soo Yoon-
dc.contributor.googleauthorChang-Ki Min-
dc.contributor.googleauthorKihyun Kim-
dc.contributor.googleauthorHyeon-Seok Eom-
dc.contributor.googleauthorKorean Multiple Myeloma Working Party-
dc.identifier.doi10.1007/s12185-020-02869-y-
dc.contributor.localIdA01017-
dc.relation.journalcodeJ01120-
dc.identifier.eissn1865-3774-
dc.identifier.pmid32449149-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12185-020-02869-y-
dc.subject.keywordAutologous-
dc.subject.keywordElderly-
dc.subject.keywordMultiple myeloma-
dc.subject.keywordStem cell-
dc.subject.keywordTransplantation-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.affiliatedAuthor김진석-
dc.citation.volume112-
dc.citation.number1-
dc.citation.startPage84-
dc.citation.endPage95-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.112(1) : 84-95, 2020-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.