Cited 3 times in
Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2020-12-01T17:31:58Z | - |
dc.date.available | 2020-12-01T17:31:58Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180317 | - |
dc.description.abstract | Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (≥ very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3-4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Japan | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Febrile Neutropenia / epidemiology | - |
dc.subject.MESH | Febrile Neutropenia / etiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multiple Myeloma / therapy* | - |
dc.subject.MESH | Nausea / epidemiology | - |
dc.subject.MESH | Nausea / etiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stem Cell Transplantation* / adverse effects | - |
dc.subject.MESH | Stomatitis / epidemiology | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jongheon Jung | - |
dc.contributor.googleauthor | Yoon Seok Choi | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Won Sik Lee | - |
dc.contributor.googleauthor | Sung-Hyun Kim | - |
dc.contributor.googleauthor | Yong Park | - |
dc.contributor.googleauthor | Seung-Shin Lee | - |
dc.contributor.googleauthor | Young Rok Do | - |
dc.contributor.googleauthor | Jae-Cheol Jo | - |
dc.contributor.googleauthor | Je-Jung Lee | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Ho-Jin Shin | - |
dc.contributor.googleauthor | Dong-Yeop Shin | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Chang-Ki Min | - |
dc.contributor.googleauthor | Kihyun Kim | - |
dc.contributor.googleauthor | Hyeon-Seok Eom | - |
dc.contributor.googleauthor | Korean Multiple Myeloma Working Party | - |
dc.identifier.doi | 10.1007/s12185-020-02869-y | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J01120 | - |
dc.identifier.eissn | 1865-3774 | - |
dc.identifier.pmid | 32449149 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12185-020-02869-y | - |
dc.subject.keyword | Autologous | - |
dc.subject.keyword | Elderly | - |
dc.subject.keyword | Multiple myeloma | - |
dc.subject.keyword | Stem cell | - |
dc.subject.keyword | Transplantation | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.citation.volume | 112 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 84 | - |
dc.citation.endPage | 95 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.112(1) : 84-95, 2020-07 | - |
dc.identifier.rimsid | 67338 | - |
dc.type.rims | ART | - |
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