Cited 27 times in
Patterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19
DC Field | Value | Language |
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dc.contributor.author | 구남수 | - |
dc.contributor.author | 김정호 | - |
dc.contributor.author | 박윤수 | - |
dc.contributor.author | 손유진 | - |
dc.contributor.author | 안진영 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 염준섭 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 현종훈 | - |
dc.date.accessioned | 2020-12-01T17:30:02Z | - |
dc.date.available | 2020-12-01T17:30:02Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180305 | - |
dc.description.abstract | Objectives: The aim of this study was to elucidate patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course of asymptomatic coronavirus disease 2019 (COVID-19). Methods: Consecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic patients with a normal body temperature and no evidence of pneumonia throughout the disease course were assigned to the asymptomatic group. The reverse transcription PCR (RT-PCR) assay was repeated every two to five days after the first follow-up RT-PCR assay. Negative conversion was defined as two consecutive negative RT-PCR assay results within a 24-h interval. Rebound of the cycle threshold (Ct) value was defined as negative from the single RT-PCR assay and positive from the following assay. Results: Among a total of 396 patients identified (median age 42.5 years (interquartile range (IQR) 25.0-55.0 years), 35.6% male), 68 (17.2%) were assigned to the asymptomatic group and 328 (82.8%) to the symptomatic group. The time until negative conversion was significantly shorter in the asymptomatic group than in the symptomatic group: median 14.5 days (IQR 11.0-21.0 days) and 18.0 days (IQR 15.0-22.0 days), respectively (p = 0.001). Rebound of Ct values was observed in 78 patients (19.7%). Conclusions: Time until negative conversion is shorter in asymptomatic COVID-19 than in symptomatic COVID-19. Rebound of Ct values is not uncommon. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asymptomatic Diseases | - |
dc.subject.MESH | Betacoronavirus / genetics* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Coronavirus Infections / diagnosis | - |
dc.subject.MESH | Coronavirus Infections / epidemiology* | - |
dc.subject.MESH | Coronavirus Infections / virology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pandemics* | - |
dc.subject.MESH | Pneumonia, Viral / diagnosis | - |
dc.subject.MESH | Pneumonia, Viral / epidemiology* | - |
dc.subject.MESH | Pneumonia, Viral / virology | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Viral Load | - |
dc.title | Patterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Jin Young Ahn | - |
dc.contributor.googleauthor | JongHoon Hyun | - |
dc.contributor.googleauthor | Yujin Sohn | - |
dc.contributor.googleauthor | Jung Ho Kim | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Yu-Kyung Park | - |
dc.contributor.googleauthor | Ho-Sung Yi | - |
dc.contributor.googleauthor | Sung Kyu Park | - |
dc.contributor.googleauthor | Bong-Ok Kim | - |
dc.contributor.googleauthor | Hyewon Kim | - |
dc.contributor.googleauthor | Jinwoo Choi | - |
dc.contributor.googleauthor | Seung-Mo Kang | - |
dc.contributor.googleauthor | Yeong Ho Choi | - |
dc.contributor.googleauthor | Hae Kyoung Yoon | - |
dc.contributor.googleauthor | Sunkyung Jung | - |
dc.contributor.googleauthor | Hyeong Nyeon Kim | - |
dc.contributor.googleauthor | Joon-Sup Yeom | - |
dc.contributor.googleauthor | Yoon Soo Park | - |
dc.identifier.doi | 10.1016/j.ijid.2020.07.070 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00902 | - |
dc.contributor.localId | A01598 | - |
dc.contributor.localId | A05924 | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02353 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A05944 | - |
dc.relation.journalcode | J01125 | - |
dc.identifier.eissn | 1878-3511 | - |
dc.identifier.pmid | 32763446 | - |
dc.subject.keyword | Asymptomatic | - |
dc.subject.keyword | COVID-19 | - |
dc.subject.keyword | Coronavirus disease 2019 | - |
dc.subject.keyword | Negative conversion | - |
dc.subject.keyword | SARS-CoV-2 | - |
dc.subject.keyword | Viral clearance | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | 구남수 | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.contributor.affiliatedAuthor | 박윤수 | - |
dc.contributor.affiliatedAuthor | 손유진 | - |
dc.contributor.affiliatedAuthor | 안진영 | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.contributor.affiliatedAuthor | 염준섭 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.contributor.affiliatedAuthor | 현종훈 | - |
dc.citation.volume | 99 | - |
dc.citation.startPage | 279 | - |
dc.citation.endPage | 285 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.99 : 279-285, 2020-10 | - |
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