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Patterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19

DC FieldValueLanguage
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author박윤수-
dc.contributor.author손유진-
dc.contributor.author안진영-
dc.contributor.author엄재선-
dc.contributor.author염준섭-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author현종훈-
dc.date.accessioned2020-12-01T17:30:02Z-
dc.date.available2020-12-01T17:30:02Z-
dc.date.issued2020-10-
dc.identifier.issn1201-9712-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180305-
dc.description.abstractObjectives: The aim of this study was to elucidate patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course of asymptomatic coronavirus disease 2019 (COVID-19). Methods: Consecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic patients with a normal body temperature and no evidence of pneumonia throughout the disease course were assigned to the asymptomatic group. The reverse transcription PCR (RT-PCR) assay was repeated every two to five days after the first follow-up RT-PCR assay. Negative conversion was defined as two consecutive negative RT-PCR assay results within a 24-h interval. Rebound of the cycle threshold (Ct) value was defined as negative from the single RT-PCR assay and positive from the following assay. Results: Among a total of 396 patients identified (median age 42.5 years (interquartile range (IQR) 25.0-55.0 years), 35.6% male), 68 (17.2%) were assigned to the asymptomatic group and 328 (82.8%) to the symptomatic group. The time until negative conversion was significantly shorter in the asymptomatic group than in the symptomatic group: median 14.5 days (IQR 11.0-21.0 days) and 18.0 days (IQR 15.0-22.0 days), respectively (p = 0.001). Rebound of Ct values was observed in 78 patients (19.7%). Conclusions: Time until negative conversion is shorter in asymptomatic COVID-19 than in symptomatic COVID-19. Rebound of Ct values is not uncommon.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAsymptomatic Diseases-
dc.subject.MESHBetacoronavirus / genetics*-
dc.subject.MESHCohort Studies-
dc.subject.MESHCoronavirus Infections / diagnosis-
dc.subject.MESHCoronavirus Infections / epidemiology*-
dc.subject.MESHCoronavirus Infections / virology-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPandemics*-
dc.subject.MESHPneumonia, Viral / diagnosis-
dc.subject.MESHPneumonia, Viral / epidemiology*-
dc.subject.MESHPneumonia, Viral / virology-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHViral Load-
dc.titlePatterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorJongHoon Hyun-
dc.contributor.googleauthorYujin Sohn-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYu-Kyung Park-
dc.contributor.googleauthorHo-Sung Yi-
dc.contributor.googleauthorSung Kyu Park-
dc.contributor.googleauthorBong-Ok Kim-
dc.contributor.googleauthorHyewon Kim-
dc.contributor.googleauthorJinwoo Choi-
dc.contributor.googleauthorSeung-Mo Kang-
dc.contributor.googleauthorYeong Ho Choi-
dc.contributor.googleauthorHae Kyoung Yoon-
dc.contributor.googleauthorSunkyung Jung-
dc.contributor.googleauthorHyeong Nyeon Kim-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.contributor.googleauthorYoon Soo Park-
dc.identifier.doi10.1016/j.ijid.2020.07.070-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA00902-
dc.contributor.localIdA01598-
dc.contributor.localIdA01598-
dc.contributor.localIdA05924-
dc.contributor.localIdA05924-
dc.contributor.localIdA02267-
dc.contributor.localIdA02267-
dc.contributor.localIdA02337-
dc.contributor.localIdA02337-
dc.contributor.localIdA02353-
dc.contributor.localIdA02353-
dc.contributor.localIdA03638-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04191-
dc.contributor.localIdA05944-
dc.contributor.localIdA05944-
dc.relation.journalcodeJ01125-
dc.identifier.eissn1878-3511-
dc.identifier.pmid32763446-
dc.subject.keywordAsymptomatic-
dc.subject.keywordCOVID-19-
dc.subject.keywordCoronavirus disease 2019-
dc.subject.keywordNegative conversion-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordViral clearance-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor박윤수-
dc.contributor.affiliatedAuthor박윤수-
dc.contributor.affiliatedAuthor손유진-
dc.contributor.affiliatedAuthor손유진-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.contributor.affiliatedAuthor최준용-
dc.contributor.affiliatedAuthor현종훈-
dc.contributor.affiliatedAuthor현종훈-
dc.citation.volume99-
dc.citation.startPage279-
dc.citation.endPage285-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.99 : 279-285, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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