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A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

DC FieldValueLanguage
dc.contributor.author안상훈-
dc.date.accessioned2020-12-01T17:29:01Z-
dc.date.available2020-12-01T17:29:01Z-
dc.date.issued2020-07-
dc.identifier.issn0168-8278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180294-
dc.description.abstractThe exclusion of other chronic liver diseases including "excess" alcohol intake has until now been necessary to establish a diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD). However, given our current understanding of the pathogenesis of MAFLD and its rising prevalence, "positive criteria" to diagnose the disease are required. In this work, a panel of international experts from 22 countries propose a new definition for the diagnosis of MAFLD that is both comprehensive and simple, and is independent of other liver diseases. The criteria are based on evidence of hepatic steatosis, in addition to one of the following three criteria, namely overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation. We propose that disease assessment and stratification of severity should extend beyond a simple dichotomous classification to steatohepatitis vs. non-steatohepatitis. The group also suggests a set of criteria to define MAFLD-associated cirrhosis and proposes a conceptual framework to consider other causes of fatty liver disease. Finally, we bring clarity to the distinction between diagnostic criteria and inclusion criteria for research studies and clinical trials. Reaching consensus on the criteria for MAFLD will help unify the terminology (e.g. for ICD-coding), enhance the legitimacy of clinical practice and clinical trials, improve clinical care and move the clinical and scientific field of liver research forward.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMohammed Eslam-
dc.contributor.googleauthorPhilip N Newsome-
dc.contributor.googleauthorShiv K Sarin-
dc.contributor.googleauthorQuentin M Anstee-
dc.contributor.googleauthorGiovanni Targher-
dc.contributor.googleauthorManuel Romero-Gomez-
dc.contributor.googleauthorShira Zelber-Sagi-
dc.contributor.googleauthorVincent Wai-Sun Wong-
dc.contributor.googleauthorJean-François Dufour-
dc.contributor.googleauthorJörn M Schattenberg-
dc.contributor.googleauthorTakumi Kawaguchi-
dc.contributor.googleauthorMarco Arrese-
dc.contributor.googleauthorLuca Valenti-
dc.contributor.googleauthorGamal Shiha-
dc.contributor.googleauthorClaudio Tiribelli-
dc.contributor.googleauthorHannele Yki-Järvinen-
dc.contributor.googleauthorJian-Gao Fan-
dc.contributor.googleauthorHenning Grønbæk-
dc.contributor.googleauthorYusuf Yilmaz-
dc.contributor.googleauthorHelena Cortez-Pinto-
dc.contributor.googleauthorClaudia P Oliveira-
dc.contributor.googleauthorPierre Bedossa-
dc.contributor.googleauthorLeon A Adams-
dc.contributor.googleauthorMing-Hua Zheng-
dc.contributor.googleauthorYasser Fouad-
dc.contributor.googleauthorWah-Kheong Chan-
dc.contributor.googleauthorNahum Mendez-Sanchez-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorLaurent Castera-
dc.contributor.googleauthorElisabetta Bugianesi-
dc.contributor.googleauthorVlad Ratziu-
dc.contributor.googleauthorJacob George-
dc.identifier.doi10.1016/j.jhep.2020.03.039-
dc.contributor.localIdA02226-
dc.relation.journalcodeJ01441-
dc.identifier.eissn1600-0641-
dc.identifier.pmid32278004-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0168827820302014-
dc.subject.keywordCirrhosis-
dc.subject.keywordDiabetes-
dc.subject.keywordDiagnostic criteria-
dc.subject.keywordMAFLD-
dc.subject.keywordMetabolic-
dc.subject.keywordNAFLD-
dc.subject.keywordObesity-
dc.subject.keywordSteatohepatitis-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.affiliatedAuthor안상훈-
dc.citation.volume73-
dc.citation.number1-
dc.citation.startPage202-
dc.citation.endPage209-
dc.identifier.bibliographicCitationJOURNAL OF HEPATOLOGY, Vol.73(1) : 202-209, 2020-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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