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Low muscle mass is associated with carotid atherosclerosis in patients with type 2 diabetes

Authors
 Da Hea Seo  ;  Yong-Ho Lee  ;  Young Ju Suh  ;  Seong Hee Ahn  ;  Seongbin Hong  ;  Young Ju Choi  ;  Byoung Wook Huh  ;  Seok Won Park  ;  Eunjig Lee  ;  So Hun Kim 
Citation
 ATHEROSCLEROSIS, Vol.305 : 19-25, 2020-07 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2020-07
Keywords
Artery plaque ; Carotid ; Carotid atherosclerosis ; Carotid intima-media thickness ; Diabetes mellitus ; Muscle ; Sarcopenia ; Skeletal ; Type 2
Abstract
Background and aims: Sarcopenia leads to metabolic and vascular abnormalities. However, little is known regarding the independent relationship between skeletal muscle mass and atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between skeletal muscle mass and carotid atherosclerosis in men and women with T2DM. Methods: In this cross-sectional study, a total of 8202 patients with T2DM were recruited from the Seoul Metabolic Syndrome cohort. Skeletal muscle mass was estimated using bioimpedance analysis, while skeletal muscle mass index (SMI, %) was defined as total skeletal muscle mass (kg)/body weight (kg) × 100. Both carotid arteries were examined by B-mode ultrasound. Carotid atherosclerosis was defined by having a carotid plaque or mean carotid intima-media thickness (IMT) ≥1.1 mm. Results: Among the entire population, 4299 (52.4%) subjects had carotid atherosclerosis. The prevalence of carotid atherosclerosis increased with decreasing SMI quartiles for both sexes. The odds ratios for carotid atherosclerosis were 2.33 (95% confidence interval [CI], 1.17-4.63) and 2.24 (95% CI, 1.06-4.741) in the lowest versus highest SMI quartile in men and women, respectively, after the adjustment for clinical risk factors. In men, the risk of atherosclerosis increased linearly with decreasing SMI quartiles (p for trend = 0.036). Conclusions: Low skeletal muscle mass was independently associated with the presence of carotid atherosclerosis in men and women with T2DM.
Full Text
https://www.sciencedirect.com/science/article/pii/S0021915020302951
DOI
10.1016/j.atherosclerosis.2020.05.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seok Won(박석원)
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180274
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