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Low High-Sensitivity C-Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW-CKD

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author남기헌-
dc.contributor.author박근형-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author이창현-
dc.contributor.author한승혁-
dc.date.accessioned2020-12-01T17:24:12Z-
dc.date.available2020-12-01T17:24:12Z-
dc.date.issued2020-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180252-
dc.description.abstractBackground Inflammation levels are lower in East Asians than in Western people. We studied the association between high-sensitivity hs-CRP (C-reactive protein) and adverse outcomes in Korean patients with chronic kidney disease. Methods and Results We included 2018 participants from the KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) between April 2011 and February 2016. The primary outcome was a composite of extended major cardiovascular events (eMACE) or all-cause mortality. The secondary end points were separate outcomes of eMACE, all-cause death, and adverse kidney outcome. We also evaluated predictive ability of hs-CRP for the primary outcome. The median hs-CRP level was 0.60 mg/L. During the mean follow-up of 3.9 years, there were 125 (6.2%) eMACEs and 80 (4.0%) deaths. In multivariable Cox analysis after adjustment of confounders, there was a graded association of hs-CRP with the primary outcome. The hazard ratios for hs-CRPs of 1.0 to 2.99 and ≥3.0 mg/L were 1.33 (95% CI, 0.87-2.03) and 2.08 (95% CI, 1.30-3.33) compared with the hs-CRP of <1.0 mg/L. In secondary outcomes, this association was consistent for eMACE and all-cause death; however, hs-CRP was not associated with adverse kidney outcomes. Finally, prediction models failed to show improvement of predictive performance of hs-CRP compared with conventional factors. Conclusions In Korean patients with chronic kidney disease, the hs-CRP level was low and significantly associated with higher risks of eMACEs and mortality. However, hs-CRP did not associate with adverse kidney outcome, and the predictive performance of hs-CRP was not strong. Registration URL: http://www.clinicaltrials.gov; Unique identifier: NCT01630486.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfJOURNAL OF THE AMERICAN HEART ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLow High-Sensitivity C-Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW-CKD-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorChanghyun Lee-
dc.contributor.googleauthorKeun Hyung Park-
dc.contributor.googleauthorYoung Su Joo-
dc.contributor.googleauthorKi Heon Nam-
dc.contributor.googleauthorTae-Ik Chang-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorJoongyub Lee-
dc.contributor.googleauthorYun Kyu Oh-
dc.contributor.googleauthorJi Yong Jung-
dc.contributor.googleauthorCurie Ahn-
dc.contributor.googleauthorKyu-Beck Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1161/JAHA.120.017980-
dc.contributor.localIdA00053-
dc.contributor.localIdA01244-
dc.contributor.localIdA01244-
dc.contributor.localIdA05973-
dc.contributor.localIdA05973-
dc.contributor.localIdA01654-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA02526-
dc.contributor.localIdA05656-
dc.contributor.localIdA05656-
dc.contributor.localIdA04304-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ01774-
dc.identifier.eissn2047-9980-
dc.identifier.pmid33092438-
dc.subject.keywordcardiovascular events-
dc.subject.keywordchronic kidney disease-
dc.subject.keywordhs‐CRP-
dc.subject.keywordkidney outcome-
dc.subject.keywordmortality-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor남기헌-
dc.contributor.affiliatedAuthor남기헌-
dc.contributor.affiliatedAuthor박근형-
dc.contributor.affiliatedAuthor박근형-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor이창현-
dc.contributor.affiliatedAuthor이창현-
dc.contributor.affiliatedAuthor한승혁-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume9-
dc.citation.number21-
dc.citation.startPagee17980-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.9(21) : e17980, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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