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Blood pressure levels and cardiovascular risk according to age in patients with diabetes mellitus: a nationwide population-based cohort study

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dc.contributor.author강석민-
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author이찬주-
dc.contributor.author조익성-
dc.date.accessioned2020-12-01T17:23:45Z-
dc.date.available2020-12-01T17:23:45Z-
dc.date.issued2020-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180249-
dc.description.abstractBackground: Little is known about age-specific target blood pressure (BP) in hypertensive patients with diabetes mellitus (DM). The aim of this study was to determine the BP level at the lowest cardiovascular risk of hypertensive patients with DM according to age. Methods: Using the Korean National Health Insurance Service database, we analyzed patients without cardiovascular disease diagnosed with both hypertension and DM from January 2002 to December 2011. Primary end-point was composite cardiovascular events including cardiovascular death, myocardial infarction and stroke. Results: Of 241,148 study patients, 35,396 had cardiovascular events during a median follow-up period of 10 years. At the age of < 70 years, the risk of cardiovascular events was lower in patients with BP < 120/70 mmHg than in those with BP 130-139/80-89 mmHg. At the age of ≥ 70, however, there were no significant differences in the risk of cardiovascular events between patients with BP 130-139/80-89 mmHg and BP < 120/70 mmHg. The risk of cardiovascular events was similar between patients with BP 130-139/80-89 mmHg and BP 120-129/70-79 mmHg, and it was significantly higher in those with BP ≥ 140/90 mmHg than in those with BP 130-139/80-89 mmHg at all ages. Conclusions: In a cohort of hypertensive patients who had DM but no history of cardiovascular disease, lower BP was associated with lower risk of cardiovascular events especially at the age of < 70. However, low BP < 130-139/80-89 mmHg was not associated with decreased cardiovascular risk, it may be better to keep the BP of 130-139/80-89 mmHg at the age of ≥ 70.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBlood pressure levels and cardiovascular risk according to age in patients with diabetes mellitus: a nationwide population-based cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHack-Lyoung Kim-
dc.contributor.googleauthorHyue Mee Kim-
dc.contributor.googleauthorChang Hee Kwon-
dc.contributor.googleauthorJeong-Hun Shin-
dc.contributor.googleauthorMi-Hyang Jung-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorDae-Hee Kim-
dc.contributor.googleauthorWoo-Hyeun Kim-
dc.contributor.googleauthorSi-Hyuck Kang-
dc.contributor.googleauthorJu-Hee Lee-
dc.contributor.googleauthorIn Jeong Cho-
dc.contributor.googleauthorIksung Cho-
dc.contributor.googleauthorJun Hyeok Lee-
dc.contributor.googleauthorDae Ryong Kang-
dc.contributor.googleauthorHae-Young Lee-
dc.contributor.googleauthorWook-Jin Chung-
dc.contributor.googleauthorSang-Hyun Ihm-
dc.contributor.googleauthorKwang Il Kim-
dc.contributor.googleauthorEun Joo Cho-
dc.contributor.googleauthorIl-Suk Sohn-
dc.contributor.googleauthorHyeon-Chang Kim-
dc.contributor.googleauthorJinho Shin-
dc.contributor.googleauthorJu Han Kim-
dc.contributor.googleauthorSung Kee Ryu-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorWook Bum Pyun-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorKi-Chul Sung-
dc.identifier.doi10.1186/s12933-020-01156-8-
dc.contributor.localIdA00037-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA03238-
dc.contributor.localIdA03888-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmid33076934-
dc.subject.keywordAge-
dc.subject.keywordCardiovascular risk-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordHypertension-
dc.subject.keywordTarget blood pressure-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor조익성-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage181-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 181, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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