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Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?

Authors
 Joohyun Park  ;  Ji Young Chang  ;  Jong Youl Kim  ;  Jong Eun Lee 
Citation
 FRONTIERS IN NEUROLOGY, Vol.11 : 578003, 2020-10 
Journal Title
 FRONTIERS IN NEUROLOGY 
Issue Date
2020-10
Keywords
ischemic stroke ; macrophages ; monocyte conversion ; monocytes ; neuroinflammation
Abstract
The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the invasion of blood cells and other macromolecules is broken down within minutes, thereby triggering the inflammation cascade, including the infiltration of peripheral blood leukocytes. In this series of processes, blood-derived monocytes have a significant effect on the outcome of ischemic stroke through neuroinflammatory responses. As neuroinflammation is a necessary and pivotal component of the reparative process after ischemic stroke, understanding the role of infiltrating monocytes in the modulation of inflammatory responses may offer a great opportunity to explore new therapies for ischemic stroke. In this review, we discuss and highlight the function and involvement of monocytes in the brain after ischemic injury, as well as their impact on tissue damage and repair.
Files in This Item:
T202004481.pdf Download
DOI
10.3389/fneur.2020.578003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Park, Joohyun(박주현) ORCID logo https://orcid.org/0000-0002-0897-4665
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180246
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