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Podoplanin-Targetable MR/OPTIC Dual-Mode Nanocomposites for Glioblastoma Multiforme in Mouse Brain Cancer

Authors
 H. LEE  ;  E. J. CHO  ;  H. SON  ;  H.O. KIM  ;  Y. HONG  ;  S. H. YANG  ;  S. J. YOON  ;  J. H. LEE  ;  J. K. SHIM  ;  J. H. CHANG  ;  S.G. KANG  ;  Y. M. HUH 
Citation
 DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, Vol.15(3) : 841-847, 2020-09 
Journal Title
 DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES 
Issue Date
2020-09
Keywords
MRI ; Optical imaging ; Brain cancer ; Glioblastoma multiforme ; Podoplanin ; GSC11
Abstract
It is very desirable to design dual-mode nanocomposites for diagnostic applications via flexible strategies. Herein, we proposed to synthesize one type of multifunctional magnetic resonance (MR)/optic nanocomposites based on manganese ferrite magnetic nanoparticles (MFNPs) modified by fluorescent podoplanin (PDPN) antibodies. MFNPs were synthesized using a thermal decomposition method and were modified by the fluorescent PDPN antibodies on their surfaces. The fluorescent PDPN antibody-conjugated MFNPs enabled strong MR imaging and fluorescence imaging due to the antibodies that targeted brain tumors. These results demonstrate that MR/optic nanocomposites have potential as precision diagnostic systems for brain cancer.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Yoon, Seon Jin(윤선진) ORCID logo https://orcid.org/0000-0002-3255-5081
Lee, Hwun Jae(이훈재)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180234
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