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Neuroprotective Effect of Antioxidants in the Brain

DC FieldValueLanguage
dc.contributor.author이배환-
dc.contributor.author차명훈-
dc.date.accessioned2020-12-01T17:19:59Z-
dc.date.available2020-12-01T17:19:59Z-
dc.date.issued2020-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180222-
dc.description.abstractThe brain is vulnerable to excessive oxidative insults because of its abundant lipid content, high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) increase susceptibility to neuronal damage and functional deficits, via oxidative changes in the brain in neurodegenerative diseases. Overabundance and abnormal levels of ROS and/or overload of metals are regulated by cellular defense mechanisms, intracellular signaling, and physiological functions of antioxidants in the brain. Single and/or complex antioxidant compounds targeting oxidative stress, redox metals, and neuronal cell death have been evaluated in multiple preclinical and clinical trials as a complementary therapeutic strategy for combating oxidative stress associated with neurodegenerative diseases. Herein, we present a general analysis and overview of various antioxidants and suggest potential courses of antioxidant treatments for the neuroprotection of the brain from oxidative injury. This review focuses on enzymatic and non-enzymatic antioxidant mechanisms in the brain and examines the relative advantages and methodological concerns when assessing antioxidant compounds for the treatment of neurodegenerative disorders.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleNeuroprotective Effect of Antioxidants in the Brain-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthorKyung Hee Lee-
dc.contributor.googleauthorMyeounghoon Cha-
dc.contributor.googleauthorBae Hwan Lee-
dc.identifier.doi10.3390/ijms21197152-
dc.contributor.localIdA02791-
dc.contributor.localIdA03994-
dc.contributor.localIdA03994-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid32998277-
dc.subject.keywordantioxidant-
dc.subject.keywordbrain-
dc.subject.keywordneurodegenerative disease-
dc.subject.keywordneuroprotection-
dc.subject.keywordoxidative stress-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.contributor.affiliatedAuthor이배환-
dc.contributor.affiliatedAuthor차명훈-
dc.contributor.affiliatedAuthor차명훈-
dc.citation.volume21-
dc.citation.number19-
dc.citation.startPage7152-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(19) : 7152, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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