Cited 15 times in
Intensity-Modulated Radiotherapy-Based Reirradiation for Head and Neck Cancer: A Multi-institutional Study by Korean Radiation Oncology Group (KROG 1707)
DC Field | Value | Language |
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dc.contributor.author | 김태형 | - |
dc.contributor.author | 이창걸 | - |
dc.date.accessioned | 2020-12-01T17:19:44Z | - |
dc.date.available | 2020-12-01T17:19:44Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180220 | - |
dc.description.abstract | Purpose: The benefits of reirradiation for head and neck cancer (HNC) have not been determined. This study evaluated the efficacy of reirradiation using intensity-modulated radiotherapy (IMRT) for recurrent or second primary HNC (RSPHNC) and identified subgroups for whom reirradiation for RSPHNC is beneficial. Materials and methods: A total of 118 patients from seven Korean institutions with RSPHNC who underwent IMRT-based reirradiation between 2006 and 2015 were evaluated through retrospective review of medical records. We assessed overall survival (OS) and local control (LC) within the radiotherapy (RT) field following IMRT-based reirradiation. Additionally, the OS curve according to the recursive partitioning analysis (RPA) suggested by the Multi-Institution Reirradiation (MIRI) Collaborative was determined. Results: At a median follow-up period of 18.5 months, OS at 2 years was 43.1%. In multivariate analysis, primary subsite, recurrent tumor size, interval between RT courses, and salvage surgery were associated with OS. With regard to the MIRI RPA model, the class I subgroup had a significantly higher OS than class II or III subgroups. LC at 2 years was 53.5%. Multivariate analyses revealed that both intervals between RT courses and salvage surgery were prognostic factors affecting LC. Grade 3 or more toxicity and grade 5 toxicity rates were 8.5% and 0.8%, respectively. Conclusion: IMRT-based reirradiation was an effective therapeutic option for patients with RSPHNC, especially those with resectable tumors and a long interval between RT courses. Further, our patients' population validated the MIRI RPA classification by showing the difference of OS according to MIRI RPA class. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Intensity-Modulated Radiotherapy-Based Reirradiation for Head and Neck Cancer: A Multi-institutional Study by Korean Radiation Oncology Group (KROG 1707) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jeongshim Lee | - |
dc.contributor.googleauthor | Tae Hyung Kim | - |
dc.contributor.googleauthor | Yeon-Sil Kim | - |
dc.contributor.googleauthor | Myungsoo Kim | - |
dc.contributor.googleauthor | Jae Won Park | - |
dc.contributor.googleauthor | Sung Hyun Kim | - |
dc.contributor.googleauthor | Hyun Ju Kim | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.identifier.doi | 10.4143/crt.2020.310 | - |
dc.contributor.localId | A05902 | - |
dc.contributor.localId | A03240 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 32632081 | - |
dc.subject.keyword | Head and neck neoplasm | - |
dc.subject.keyword | Intensity modulated radiotherapy | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Reirradiation | - |
dc.contributor.alternativeName | Kim, Taehyung | - |
dc.contributor.affiliatedAuthor | 김태형 | - |
dc.contributor.affiliatedAuthor | 이창걸 | - |
dc.citation.volume | 52 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1040 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.52(4) : 1031-1040, 2020-10 | - |
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