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Clinical Implications of Thrombocytopenia at Cardiogenic Shock Presentation: Data from a Multicenter Registry

DC FieldValueLanguage
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author안철민-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author홍성진-
dc.date.accessioned2020-12-01T17:19:26Z-
dc.date.available2020-12-01T17:19:26Z-
dc.date.issued2020-10-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180219-
dc.description.abstractPurpose: Thrombocytopenia (platelet count <150×10³/μL) is associated with poor outcomes in various critical illness settings. However, the prognostic value of platelet count in patients with cardiogenic shock (CS) remains unclear. Materials and methods: We enrolled 1202 patients between January 2014 and December 2018 from a multicenter retrospective-prospective cohort registry of CS. Clinical characteristics and treatment outcomes were compared between the patients with and without thrombocytopenia. Results: At presentation with CS, 244 (20.3%) patients had thrombocytopenia. The patients with thrombocytopenia had lower blood pressure, hemoglobin level, and worse liver and renal functions compared to the patients without. During hospitalization, the patients with thrombocytopenia had more frequent gastrointestinal bleeding (10.5% vs. 3.8%, p=0.009), sepsis (8.3% vs. 2.6%, p=0.013), requirement of renal replacement therapy (36.5% vs. 18.9%, p<0.001), requirement of mechanical ventilation (65.2% vs. 54.4%, p=0.003), longer intensive care unit stay (8 days vs. 4 days, p<0.001), and thirty-day mortality (40.2% vs. 28.5%, p<0.001) compared to those without. In addition, the platelet count was an independent predictor of 30-day mortality (per 103/μL decrease; adjusted hazard ratio: 1.002, 95% confidence interval: 1.000-1.003, p=0.021). Conclusion: Thrombocytopenia at CS presentation was associated with worse clinical findings, higher frequencies of complications, and longer stay at the intensive care unit. Also, thrombocytopenia was independently associated with increased 30-day mortality. (Clinical trial registration No. NCT02985008).-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCohort Studies-
dc.subject.MESHCritical Illness-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Hemorrhage / epidemiology-
dc.subject.MESHHumans-
dc.subject.MESHIntensive Care Units / statistics & numerical data*-
dc.subject.MESHLength of Stay / statistics & numerical data*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMulticenter Studies as Topic-
dc.subject.MESHPlatelet Count-
dc.subject.MESHPrevalence-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegistries / statistics & numerical data*-
dc.subject.MESHRespiration, Artificial / statistics & numerical data-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSepsis / blood-
dc.subject.MESHSepsis / epidemiology-
dc.subject.MESHShock, Cardiogenic* / diagnosis-
dc.subject.MESHShock, Cardiogenic* / mortality-
dc.subject.MESHShock, Cardiogenic* / therapy-
dc.subject.MESHThrombocytopenia* / diagnosis-
dc.subject.MESHThrombocytopenia* / mortality-
dc.subject.MESHThrombocytopenia* / therapy-
dc.subject.MESHTreatment Outcome-
dc.titleClinical Implications of Thrombocytopenia at Cardiogenic Shock Presentation: Data from a Multicenter Registry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyeok Hee Lee-
dc.contributor.googleauthorSung Jin Hong-
dc.contributor.googleauthorChul Min Ahn-
dc.contributor.googleauthorJeong Hoon Yang-
dc.contributor.googleauthorHyeon Cheol Gwon-
dc.contributor.googleauthorJung Sun Kim-
dc.contributor.googleauthorByeong Keuk Kim-
dc.contributor.googleauthorYoung Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorMyeong Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi10.3349/ymj.2020.61.10.851-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA00961-
dc.contributor.localIdA02269-
dc.contributor.localIdA02269-
dc.contributor.localIdA03448-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA04391-
dc.contributor.localIdA04403-
dc.contributor.localIdA04403-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid32975059-
dc.subject.keywordCardiogenic shock-
dc.subject.keywordmortality-
dc.subject.keywordplatelet-
dc.subject.keywordprognosis-
dc.subject.keywordthrombocytopenia-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.affiliatedAuthor고영국-
dc.contributor.affiliatedAuthor김병극-
dc.contributor.affiliatedAuthor김병극-
dc.contributor.affiliatedAuthor김중선-
dc.contributor.affiliatedAuthor김중선-
dc.contributor.affiliatedAuthor안철민-
dc.contributor.affiliatedAuthor안철민-
dc.contributor.affiliatedAuthor장양수-
dc.contributor.affiliatedAuthor장양수-
dc.contributor.affiliatedAuthor최동훈-
dc.contributor.affiliatedAuthor최동훈-
dc.contributor.affiliatedAuthor홍명기-
dc.contributor.affiliatedAuthor홍명기-
dc.contributor.affiliatedAuthor홍성진-
dc.contributor.affiliatedAuthor홍성진-
dc.citation.volume61-
dc.citation.number10-
dc.citation.startPage851-
dc.citation.endPage859-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.61(10) : 851-859, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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