Cited 4 times in
Upfront autologous hematopoietic stem cell transplantation for high-risk patients with double-expressor diffuse large B cell lymphoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김유리 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 이정연 | - |
dc.contributor.author | 장지은 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 정해림 | - |
dc.contributor.author | 김윤덕 | - |
dc.date.accessioned | 2020-12-01T17:16:54Z | - |
dc.date.available | 2020-12-01T17:16:54Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180201 | - |
dc.description.abstract | Although MYC and BCL2 co-expression in diffuse large B cell lymphoma (DLBCL) is associated with inferior prognosis, it remains uncertain whether upfront autologous hematopoietic stem cell transplantation (ASCT) is beneficial in this lymphoma. This study aimed to investigate whether ASCT consolidation could have a positive role for patients with MYC and BCL2 co-expression (double-expressor lymphoma, DEL). We retrospectively evaluated 67 DLBCL patients who underwent upfront ASCT following rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy. The 5-year overall survival (OS) and progression-free survival (PFS) were 82.3% and 79.2%, respectively. There were 23 (34.3%) patients with DEL and 51 (76.1%) patients with non-germinal center B cell (GCB) subtype. The 5-year OS and PFS of patients with DEL were not different from those with non-DEL (P = 0.429 and P = 0.614, respectively). No survival difference for OS and PFS was also observed between GCB and non-GCB subtypes (P = 0.950 and P = 0.901, respectively). The OS and PFS were comparable for patients with DEL and non-DEL and both GCB and non-GCB subtypes. In conclusion, MYC and BCL2 co-expression did not have a poor prognostic impact among high-risk patients with DLBCL treated with upfront ASCT regardless of molecular classification. This preliminary study suggested that the role of consolidative ASCT is needed to be evaluated in a prospective randomized clinical trial. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols / therapeutic use | - |
dc.subject.MESH | Cyclophosphamide / therapeutic use | - |
dc.subject.MESH | Doxorubicin / therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation / methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse / diagnosis | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse / genetics* | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse / therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prednisone / therapeutic use | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2 / biosynthesis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2 / genetics* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc / biosynthesis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc / genetics* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Transplantation, Autologous / methods | - |
dc.subject.MESH | Vincristine / therapeutic use | - |
dc.subject.MESH | Young Adult | - |
dc.title | Upfront autologous hematopoietic stem cell transplantation for high-risk patients with double-expressor diffuse large B cell lymphoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.contributor.googleauthor | Soo-Jeong Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Haerim Chung | - |
dc.contributor.googleauthor | Jung Yeon Lee | - |
dc.contributor.googleauthor | Ji Eun Jang | - |
dc.contributor.googleauthor | Yundeok Kim | - |
dc.contributor.googleauthor | Woo-Ick Yang | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.identifier.doi | 10.1007/s00277-020-04043-0 | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A00779 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A03114 | - |
dc.contributor.localId | A03477 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04674 | - |
dc.relation.journalcode | J00161 | - |
dc.identifier.eissn | 1432-0584 | - |
dc.identifier.pmid | 32390113 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00277-020-04043-0 | - |
dc.subject.keyword | Autologous hematopoietic stem cell transplantation | - |
dc.subject.keyword | BCL2 expression | - |
dc.subject.keyword | Diffuse large B cell lymphoma | - |
dc.subject.keyword | Double-expressor lymphoma | - |
dc.subject.keyword | MYC expression | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | 김수정 | - |
dc.contributor.affiliatedAuthor | 김유리 | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.contributor.affiliatedAuthor | 민유홍 | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.contributor.affiliatedAuthor | 윤선옥 | - |
dc.contributor.affiliatedAuthor | 이정연 | - |
dc.contributor.affiliatedAuthor | 장지은 | - |
dc.contributor.affiliatedAuthor | 정준원 | - |
dc.contributor.affiliatedAuthor | 정해림 | - |
dc.citation.volume | 99 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2149 | - |
dc.citation.endPage | 2157 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, Vol.99(9) : 2149-2157, 2020-09 | - |
dc.identifier.rimsid | 67365 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.