Cited 7 times in

The impact of early adjuvant chemotherapy in rectal cancer

DC Field Value Language
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author이강영-
dc.contributor.author조민수-
dc.contributor.author허혁-
dc.date.accessioned2020-12-01T17:10:57Z-
dc.date.available2020-12-01T17:10:57Z-
dc.date.issued2020-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180156-
dc.description.abstractPurposes: Although adjuvant chemotherapy (AC) has been established as a standard of treatment for advanced rectal cancer, there is no guideline regarding the timing of AC initiation. In this study, we aimed to evaluate the oncologic outcome of early AC initiation and clarify the ideal time to AC among rectal cancer patients receiving preoperative chemo-radiotherapy (preCRT). Methods: The medical records of 719 patients who underwent curative resection followed by AC for rectal cancer were analyzed retrospectively. Data distributions were compared according to the calculated cut-off for AC initiation, survival results, and chemotherapy-induced toxicity. Additionally, patients were divided into two groups according to preCRT status and compared with respect to differences in the optimal time to AC. Results: Overall, a cut-off time point of 20 days after surgery for AC initiation was identified as the optimal interval; this yielded a significant difference in disease-free survival but no significant difference in AC toxicity. In the cut-off analysis of patients treated without preCRT, 19 days was identified as the optimal time to AC. However, for patients treated with preCRT, no significant value affected the survival outcome. Conclusions: Earlier initiation of AC (within approximately 3 weeks) was associated with better oncological outcomes among patients with rectal cancer. Additionally, the optimal timing of AC was unclear among patients who received preCRT; this might be attributable to an undetermined role of AC after preCRT or the effects of complications such as anastomotic leakage.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols / adverse effects*-
dc.subject.MESHChemotherapy, Adjuvant / methods*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRectal Neoplasms / drug therapy*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSecondary Prevention / methods*-
dc.subject.MESHTreatment Outcome-
dc.titleThe impact of early adjuvant chemotherapy in rectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorGyoung Tae Noh-
dc.contributor.googleauthorJeonghee Han-
dc.contributor.googleauthorMin Soo Cho-
dc.contributor.googleauthorHyuk Hur-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorByung Soh Min-
dc.identifier.doi10.1371/journal.pone.0228060-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA02640-
dc.contributor.localIdA03817-
dc.contributor.localIdA04373-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid32004327-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor민병소-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor조민수-
dc.contributor.affiliatedAuthor허혁-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPagee0228060-
dc.identifier.bibliographicCitationPLOS ONE, Vol.15(1) : e0228060, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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