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Immunosuppressive role of CD11b + CD33 + HLA-DR - myeloid-derived suppressor cells-like blast subpopulation in acute myeloid leukemia

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author장지은-
dc.contributor.author정준원-
dc.contributor.author정해림-
dc.contributor.author현신영-
dc.date.accessioned2020-12-01T17:06:44Z-
dc.date.available2020-12-01T17:06:44Z-
dc.date.issued2020-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180128-
dc.description.abstractObjective: Myeloid-derived suppressor cells (MDSCs) facilitate tumor growth and development by suppressing T cell function; however, their role in acute myeloid leukemia (AML) remains unclear. Here, we investigated the immunosuppressive role and prognostic value of blasts with an MDSC-like phenotype. Methods: CD11b+ CD33+ HLA-DR- MDSC-like blasts from bone marrow mononuclear cells of patients with AML were analyzed. To investigate their T cell-suppressing function, MDSC-like blasts were isolated using flow cytometry and co-cultured with CD8+ cytotoxic T cells and NB4 leukemic cells. Treatment outcomes were then compared between the MDSC-like blasts low (≤9.76%) and high (>9.76%) groups to identify clinical significance. Results: MDSC-like blasts showed higher expression of arginase-1 and inducible nitric oxide synthase. Isolated MDSC-like blasts significantly suppressed CD8+ T cell proliferation induced by phytohemagglutinin A. NB4 cell proliferation was significantly suppressed upon co-culture with CD8+ cytotoxic T cells and partially restored upon co-culture with MDSC-like blasts. Patients with high MDSC-like blasts at diagnosis showed substantially shorter overall survival and leukemia-free survival relative to low MDSC-like blasts patients, with subgroup analysis showing statistically significant differences in patients not receiving allogeneic hematopoietic stem cell transplantation. Conclusion: We demonstrated that MDSC-like blasts drive AML-specific immune-escape mechanisms by suppressing T cell proliferation and restoring T cell-suppressed NB4 cell proliferation, with clinically higher fractions of MDSC-like blasts at diagnosis resulting in poor prognosis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons Ltd.-
dc.relation.isPartOfCANCER MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImmunosuppressive role of CD11b + CD33 + HLA-DR - myeloid-derived suppressor cells-like blast subpopulation in acute myeloid leukemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorShin Young Hyun-
dc.contributor.googleauthorEun Jung Na-
dc.contributor.googleauthorJi Eun Jang-
dc.contributor.googleauthorHaerim Chung-
dc.contributor.googleauthorSoo Jeong Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorJee Hyun Kong-
dc.contributor.googleauthorKwang Yong Shim-
dc.contributor.googleauthorJong In Lee-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJune-Won Cheong-
dc.identifier.doi10.1002/cam4.3360-
dc.contributor.localIdA00633-
dc.contributor.localIdA01017-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA01407-
dc.contributor.localIdA03477-
dc.contributor.localIdA03477-
dc.contributor.localIdA03729-
dc.contributor.localIdA03729-
dc.contributor.localIdA04674-
dc.contributor.localIdA04674-
dc.contributor.localIdA04381-
dc.contributor.localIdA04381-
dc.relation.journalcodeJ00449-
dc.identifier.eissn2045-7634-
dc.identifier.pmid32780544-
dc.subject.keywordacute myeloid leukemia-
dc.subject.keywordarginase-
dc.subject.keywordinducible nitric oxide synthase-
dc.subject.keywordmyeloid-derived suppressor cells-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.affiliatedAuthor김수정-
dc.contributor.affiliatedAuthor김진석-
dc.contributor.affiliatedAuthor김진석-
dc.contributor.affiliatedAuthor민유홍-
dc.contributor.affiliatedAuthor민유홍-
dc.contributor.affiliatedAuthor장지은-
dc.contributor.affiliatedAuthor장지은-
dc.contributor.affiliatedAuthor정준원-
dc.contributor.affiliatedAuthor정준원-
dc.contributor.affiliatedAuthor정해림-
dc.contributor.affiliatedAuthor정해림-
dc.contributor.affiliatedAuthor현신영-
dc.contributor.affiliatedAuthor현신영-
dc.citation.volume9-
dc.citation.number19-
dc.citation.startPage7007-
dc.citation.endPage7017-
dc.identifier.bibliographicCitationCANCER MEDICINE, Vol.9(19) : 7007-7017, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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