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Antimicrobial activity of Curcuma xanthorrhiza nanoemulsions on Streptococcus mutans biofilms

Authors
 Mu-Yeol Cho  ;  Si-Mook Kang  ;  Eun-Song Lee  ;  Baek-Il Kim 
Citation
 BIOFOULING, Vol.36(7) : 825-33, 2020-08 
Journal Title
 BIOFOULING 
ISSN
 0892-7014 
Issue Date
2020-08
Keywords
Curcuma xanthorrhiza ; Nanoemulsion ; antimicrobial ; biofilm ; dental disease
Abstract
In this study, an optimal nanoemulsion formulation for Curcuma xanthorrhiza oil (Xan) was investigated using different sonication times. The antimicrobial effects of the nanoemulsion, the original emulsion, distilled water (DW), and Listerine, on Streptococcus mutans biofilms were compared. The optimum ultrasonic time, determined in terms of droplet size and stability, was found to be 10 min. Cell viability was the lowest on exposure to the nanoemulsion, and significantly different compared with exposure to DW or Listerine. The emulsion's effect was similar to that of the nanoemulsion, but was non-uniform with a high interquartile range. Confocal microscope analysis revealed that the live/dead cell ratio in the nanoemulsion was 50% and 40% less than those in DW and Listerine, respectively. Biofilm treated with the nanoemulsion was thinner than biofilms exposed to the other treatments. Xan nanoemulsions exhibited stable and strong antimicrobial effects due to nano-sized particles, highlighting their potential use in oral health treatment.
Full Text
https://www.tandfonline.com/doi/full/10.1080/08927014.2020.1823376
DOI
10.1080/08927014.2020.1823376
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Lee, Eun Song(이은송) ORCID logo https://orcid.org/0000-0002-2949-4783
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180109
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