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Image quality of 4D in-treatment CBCT acquired during lung SBRT using FFF beam: a phantom study

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dc.contributor.author금기창-
dc.contributor.author김지훈-
dc.contributor.author김진성-
dc.contributor.author박광우-
dc.contributor.author이호-
dc.contributor.author홍채선-
dc.date.accessioned2020-12-01T17:00:43Z-
dc.date.available2020-12-01T17:00:43Z-
dc.date.issued2020-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180083-
dc.description.abstractBackground: Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to acquire CBCT during stereotactic body radiation therapy (SBRT) using flattening-filter free X-ray beams, in which a high radiation dose is delivered. This study presents quantitative evaluation results of the image quality in four-dimensional (4D) in-treatment CBCT acquired during SBRT delivery. Methods: The impact of megavoltage (MV) scatter and acquisition parameters on the image quality was evaluated using Catphan 503 and XSight lung tracking phantoms. The in-treatment CBCT images of the phantoms were acquired while delivering 16 SBRT plans. The uniformity, contrast, and contrast-to-noise ratio (CNR) of the in-treatment CBCT images were calculated and compared to those of CBCT images acquired without SBRT delivery. Furthermore, the localizing accuracy of the moving target in the XSight lung phantom was evaluated for 10 respiratory phases. Results: The CNR of the 3D-reconstucted Catphan CBCT images was reduced from 6.3 to 2.6 due to the effect of MV treatment scatter. Both for the Catphan and XSight phantoms, the CBCT image quality was affected by the tube current and monitor units (MUs) of the treatment plan. The lung target in the XSight tracking phantom was most visible for extreme phases; the mean CNRs of the lung target in the in-treatment CBCT images (with 40 mA tube current) across the SBRT plans were 3.2 for the end-of-exhalation phase and 3.0 for the end-of-inhalation phase. The lung target was localized with sub-millimeter accuracy for the extreme respiratory phases. Conclusions: Full-arc acquisition with an increased tube current (e.g. 40 mA) is recommended to compensate for degradation in the CBCT image quality due to unflattened MV beam scatter. Acquiring in-treatment CBCT with a high-MU treatment beam is also suggested to improve the resulting CBCT image quality.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfRADIATION ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImage quality of 4D in-treatment CBCT acquired during lung SBRT using FFF beam: a phantom study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJihun Kim-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorHo Lee-
dc.contributor.googleauthorChae-Seon Hong-
dc.contributor.googleauthorKwangwoo Park-
dc.contributor.googleauthorJin Sung Kim-
dc.identifier.doi10.1186/s13014-020-01668-3-
dc.contributor.localIdA00272-
dc.contributor.localIdA05823-
dc.contributor.localIdA04548-
dc.contributor.localIdA01432-
dc.contributor.localIdA03323-
dc.contributor.localIdA05846-
dc.relation.journalcodeJ02591-
dc.identifier.eissn1748-717X-
dc.identifier.pmid32977808-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.affiliatedAuthor금기창-
dc.contributor.affiliatedAuthor김지훈-
dc.contributor.affiliatedAuthor김진성-
dc.contributor.affiliatedAuthor박광우-
dc.contributor.affiliatedAuthor이호-
dc.contributor.affiliatedAuthor홍채선-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage224-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY, Vol.15(1) : 224, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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