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Emerging Concepts of Motor Reserve in Parkinson's Disease

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2020-12-01T16:58:03Z-
dc.date.available2020-12-01T16:58:03Z-
dc.date.issued2020-09-
dc.identifier.issn2093-4939-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180065-
dc.description.abstractThe concept of cognitive reserve (CR) in Alzheimer's disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson's disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual's capacity to tolerate PD pathology, which can be maintained throughout disease progression.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Movement Disorders Society-
dc.relation.isPartOfJOURNAL OF MOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEmerging Concepts of Motor Reserve in Parkinson's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.identifier.doi10.14802/jmd.20029-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ01610-
dc.identifier.eissn2005-940X-
dc.identifier.pmid32854486-
dc.subject.keywordDopamine transporter-
dc.subject.keywordMotor reserve-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordPositron-emission tomography-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage171-
dc.citation.endPage184-
dc.identifier.bibliographicCitationJOURNAL OF MOVEMENT DISORDERS, Vol.13(3) : 171-184, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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